Magnetic Resonance–Guided Coronary Artery Stent Placement in a Swine Model
Magnetic Resonance–Guided Coronary Artery Stent Placement in a Swine Model
复制标题
磁共振引导下猪模型冠状动脉支架置入术
DOI：
10.1161/hc0702.104165
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
A. Buecker
中科院分区：
文献类型：
--
作者：
E. Spuentrup;A. Ruebben;T. Schaeffter;W. Manning;R. Günther;A. Buecker
背景-磁共振（MR）引导的冠状动脉支架置入术是一项具有挑战性的血管介入治疗，因为冠状动脉的尺寸很小，加上呼吸和心动周期中的不断运动。这些障碍需要更高的时间和更高的空间分辨率实时MR成像技术相比，介入外周MR血管造影。方法和结果-在1.5 T临床全身介入MR扫描仪上实施了一种新的超快实时MR成像技术，该技术结合了稳态自由旋进（SSFP）和径向k空间采样（rSSFP），用于高信噪比和运动伪影抑制。滑动窗口重建技术产生的帧速率为15/s，允许在自由呼吸期间进行数据采集，而无需心脏触发。使用镍钛合金导丝和被动器械可视化，将11枚球囊扩张式不锈钢冠状动脉支架置入7只猪（体重40 - 70 kg）的双侧冠状动脉中。通过导航器门控自由呼吸ECG触发的三维SSFP冠状动脉MRA序列控制冠状动脉支架的位置，并在离体心脏上进行目视确认。所提供的实时MR成像序列可靠地允许在所有猪中进行无运动伪影的高质量冠状动脉MR荧光透视。11枚冠状动脉支架中有10枚在MR引导下正确置入。由于球囊尺寸过小，1枚支架从左冠状动脉主干近端脱落。在实时MR成像过程中正确预测了支架脱位。结论-所提出的方法允许在猪模型中进行实时MR引导的冠状动脉支架置入。
Background—Magnetic resonance (MR)–guided coronary artery stent placement is a challenging vascular intervention because of the small size of the coronary arteries combined with incessant motion during the respiratory and cardiac cycles. These obstacles necessitate higher temporal and higher spatial resolution real-time MR imaging techniques when compared with interventional peripheral MR angiography. Methods and Results—A new, ultrafast, real-time MR imaging technique that combines steady-state free precession (SSFP) for high signal-to-noise ratio and radial k-space sampling (rSSFP) for motion artifact suppression was implemented on a 1.5-T clinical whole-body interventional MR scanner. The sliding window reconstruction technique yielded a frame rate of 15/s allowing for data acquisition during free breathing and without cardiac triggering. Eleven balloon-expandable stainless steel coronary stents were placed in both coronary arteries of 7 pigs (40 to 70 kg body weight) using a nitinol guidewire and passive device visualization. Position of the coronary stents was controlled by a navigator-gated free-breathing ECG–triggered three-dimensional SSFP coronary MRA sequence and confirmed visually on the ex vivo heart. The presented real-time MR imaging sequence reliably allowed for high-quality coronary MR fluoroscopy without motion artifacts in all pigs. Ten of 11 coronary stents were correctly placed under MR guidance. One stent dislodged proximally from the left main coronary artery because of too-small balloon size. Stent dislocation was correctly predicted during real-time MR imaging. Conclusion—The presented approach allows for real-time MR-guided coronary artery stent placement in a swine model.
影响因子：
158.5
作者：
Kim, RJ;Wu, E;Judd, RM
通讯作者：
Judd, RM
影响因子：
37.8
作者：
Lardo, AC;McVeigh, ER;Halperin, HR
通讯作者：
Halperin, HR