A qualitative study to evaluate physician attitudes regarding omission of surgery among exceptional responders to neoadjuvant systemic therapy for breast cancer (NRG-CC006).
A qualitative study to evaluate physician attitudes regarding omission of surgery among exceptional responders to neoadjuvant systemic therapy for breast cancer (NRG-CC006).
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一项定性研究，旨在评估医师对新辅助乳腺癌全身治疗的特殊反应者（NRG-CC006）的态度。
DOI：
10.1007/s10549-021-06172-0
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发表时间：
2021-06
影响因子：
3.8
通讯作者：
Jagsi R
中科院分区：
文献类型：
--
作者：
Gharzai LA;Szczygiel LA;Shumway DA;Bandos H;Julian TB;Mamounas EP;White J;De Los Santos JF;Basik M;Ganz PA;Jagsi R
Accrual to clinical trials that challenge well-established treatment paradigms represents a unique challenge. Physician opinions on investigation of a novel approach to breast cancer treatment, in which patients with complete response to neoadjuvant chemotherapy are offered omission of lumpectomy, is unknown. NRG-CC006 sought to describe physician attitudes toward a novel approach to breast cancer treatment. We recruited 18 participants in the fields of surgery, medical oncology, and radiation oncology to participate in semi-structured telephone interviews. Main outcomes are qualitative themes associated with omission of surgery. Of 18 interview participants, specialty and gender were evenly represented across surgery, medical oncology, and radiation oncology. Qualitative themes included general attitudes toward treatment de-escalation, stakeholder considerations, and trial/protocol considerations. The vast majority of participants expressed interest in investigation of omission of surgery, with all participants endorsing need for further investigation into treatment de-escalation. Stakeholder considerations in opening such a trial emphasized need for multidisciplinary involvement, and particularly, the unique role of surgeons as gatekeepers in breast cancer treatment. Finally, participants endorsed a need for further foundational studies to develop ways to predict complete pathologic response to chemotherapy without surgical intervention. Physicians expressed interest in investigating a novel approach to breast cancer treatment that would omit surgery in complete responders to neoadjuvant chemotherapy. Multidisciplinary input, and specifically surgeon engagement, will be key to the success of future investigations. Ongoing work to develop approaches to predict pathologic complete response accurately is needed to achieve the promise of this idea. BR005: NCT03188393 June 13, 2017
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DOI：
10.1056/nejmoa1804710
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sparano JA;Gray RJ;Makower DF;Pritchard KI;Albain KS;Hayes DF;Geyer CE Jr;Dees EC;Goetz MP;Olson JA Jr;Lively T;Badve SS;Saphner TJ;Wagner LI;Whelan TJ;Ellis MJ;Paik S;Wood WC;Ravdin PM;Keane MM;Gomez Moreno HL;Reddy PS;Goggins TF;Mayer IA;Brufsky AM;Toppmeyer DL;Kaklamani VG;Berenberg JL;Abrams J;Sledge GW Jr
通讯作者：
Sledge GW Jr
影响因子：
120.7
作者：
Giacomini, MK;Cook, DJ
通讯作者：
Cook, DJ
影响因子：
3.6
作者：
Scherer, Laura D.;Shaffer, Victoria A.;Zikmund-Fisher, Brian J.
通讯作者：
Zikmund-Fisher, Brian J.
影响因子：
51.1
作者：
Krag, David N.;Anderson, Stewart J.;Julian, Thomas B.;Brown, Ann M.;Harlow, Seth P.;Costantino, Joseph P.;Ashikaga, Takamaru;Weaver, Donald L.;Mamounas, Eleftherios P.;Jalovec, Lynne M.;Frazier, Thomas G.;Noyes, R. Dirk;Robidoux, Andre;Scarth, Hugh M. C.;Wolmark, Norman
通讯作者：
Wolmark, Norman
影响因子：
3.8
作者：
Lee, Han-Byoel;Han, Wonshik;Noh, Dong-Young
通讯作者：
Noh, Dong-Young