Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis.
Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis.
复制标题
DOI：
10.1183/09031936.00050911
复制
发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Collard HR
中科院分区：
文献类型：
--
作者：
Lee JS;Song JW;Wolters PJ;Elicker BM;King TE Jr;Kim DS;Collard HR
一些特发性肺纤维化患者的呼吸状态出现急性加重，导致大量发病和死亡。胃内容物的隐匿性吸入被认为是导致这些急性加重的一种可能机制。我们试图确定胃蛋白酶（胃误吸的标志物）在特发性肺纤维化急性加重期患者的支气管肺泡灌洗液中是否高于稳定期患者。在一项对特征良好的患者进行的病例对照研究中获得灌洗样本。使用标准标准定义急性加重。比较病例组和对照组灌洗液胃蛋白酶水平，并与临床特征和病程相关。确定了24例急性加重病例和30例稳定对照。两组之间的基线人口统计学无显著差异。胃蛋白酶水平是急性加重状态的指标（p=0.04）。平均而言，急性加重患者的胃蛋白酶水平高于稳定对照组。这种差异是由胃蛋白酶水平≥70 ng·mL−1的8例患者（33%）亚组引起的。胃蛋白酶水平不是生存时间的独立预测因子。这些结果提示隐匿性吸入可能在某些特发性肺纤维化急性加重病例中起作用。
Some patients with idiopathic pulmonary fibrosis experience acute exacerbations in their respiratory status leading to substantial morbidity and mortality. Occult aspiration of gastric contents has been proposed as one possible mechanism leading to these acute exacerbations. We sought to determine whether pepsin, amarker of gastric aspiration, is elevated in bronchoalveolar lavage fluid obtained from patients during acute exacerbation of idiopathic pulmonary fibrosis, compared with that obtained in stable disease. Lavage samples were obtained in a case–control study of well-characterised patients. Acute exacerbation was defined using standard criteria. Levels of lavage pepsin were compared in cases and controls, and were correlated with clinical features and disease course. 24 cases with acute exacerbations and 30 stable controls were identified. There were no significant differences in baseline demographics between the two groups. Pepsin level was an indicator of acute exacerbation status (p=0.04). On average, pepsin appeared higher in patients with acute exacerbations compared with stable controls. This difference was driven by a subgroup of eight patients (33%) with pepsin levels ≥70 ng·mL−1. Pepsin level was not an independent predictor of survival time. These results suggest occult aspiration may play a role in some cases of acute exacerbation of idiopathic pulmonary fibrosis.
登录
查看更多内容
DOI：
10.1016/j.jtcvs.2006.09.085
发表时间：
2007-04-01
影响因子：
6
作者：
Sweet, Matthew P.;Patti, Marco G.;Theodore, Pierre R.
通讯作者：
Theodore, Pierre R.
DOI：
10.1164/rccm.200602-163oc
发表时间：
2006-10-01
影响因子：
24.7
作者：
Raghu, Ganesh;Weycker, Derek;Oster, Gerry
通讯作者：
Oster, Gerry
影响因子：
3.6
作者：
Ufberg, JW;Bushra, JS;Kueppers, F
通讯作者：
Kueppers, F
影响因子：
24.3
作者：
Raghu, G;Freudenberger, TD;Pellegrini, CA
通讯作者：
Pellegrini, CA
DOI：
10.1164/ajrccm.158.6.9804105
发表时间：
1998-12-01
影响因子：
24.7
作者：
Tobin, RW;Pope, CE;Raghu, G
通讯作者：
Raghu, G