Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register--the EPIC-2-NOAR Study).
Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register--the EPIC-2-NOAR Study).
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利用生活方式因素来识别炎症性多关节炎风险较高的个体（来自欧洲诺福克癌症前瞻性调查和诺福克关节炎登记册 - EPIC-2-NOAR 研究的结果）。
DOI：
10.1136/annrheumdis-2012-202481
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发表时间：
2014-01
影响因子：
27.4
通讯作者：
Bruce IN
中科院分区：
文献类型：
--
作者：
Lahiri M;Luben RN;Morgan C;Bunn DK;Marshall T;Lunt M;Verstappen SM;Symmons DP;Khaw KT;Wareham N;Bruce IN
To investigate the association of lifestyle factors with risk of inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). The European Prospective Investigation of Cancer, Norfolk, UK (EPIC-Norfolk) gathered lifestyle data from participants aged 40–79 years from 1993 to 1997. Individuals who subsequently developed IP were identified by linkage with the Norfolk Arthritis Register. A Cox proportional hazard model was developed, and a score assigned to each risk factor to calculate the odds of developing IP. 25 455 EPIC participants were followed for a median (IQR) of 14.2 (12.9, 15.3) years; 184 developed incident IP (138 cumulatively fulfilled criteria for RA; 107 were seropositive). Pack-years of smoking were associated with increased risk of IP and RA in men (HR 1.21 (95% CI 1.08 to 1.37) per 10-pack-years) and seropositive IP (HR 1.24 (95% CI 1.10 to 1.41)) for all. Diabetes mellitus was associated with increased risk of IP (HR 2.54 (95% CI 1.26 to 5.09)), while alcohol (HR 0.86 (95% CI 0.74 to 0.99) per unit/day) and higher social class (HR 0.36 (95% CI 0.15 to 0.89) for professionals vs manual workers) were associated with reduced risk. Body mass index was associated with seronegative IP (HR 2.75 (95% CI 1.39 to 5.46) for obese vs normal-weight participants). In women, parity (HR 2.81 (95% CI 1.37 to 5.76) for ≥2 vs no children) was associated with increased risk, and breast feeding (HR 0.66 (95% CI 0.46 to 0.94) for every 52 weeks of breast feeding) was inversely associated with risk. Risk factors from the model were used to generate a ‘risk score’. A total of 1159 (8.4%) women had scores reflecting a >3-fold increased risk of IP over those with a score of 0. Several easily ascertained clinical and lifestyle factors can be used to stratify populations for risk of IP.
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影响因子：
27.4
作者：
HANNAFORD, PC;KAY, CR;HIRSCH, S
通讯作者：
HIRSCH, S
影响因子：
5.5
作者：
Goodson, NJ;Silman, AJ;Symmons, DPM
通讯作者：
Symmons, DPM
影响因子：
--
作者：
Guthrie, Katherine A.;Dugowson, Carin E.;Nelson, J. Lee
通讯作者：
Nelson, J. Lee
影响因子：
27.4
作者：
HAZES, JMW;DIJKMANS, BAC;CATS, A
通讯作者：
CATS, A
DOI：
10.1093/rheumatology/ker299
发表时间：
2012-03
期刊：
Rheumatology (Oxford, England)
影响因子：
--
作者：
Lahiri M;Morgan C;Symmons DP;Bruce IN
通讯作者：
Bruce IN