Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis
Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis
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艰难梭菌诱导的伪膜性结肠炎中血管和淋巴聚集体 P 物质受体表达增加
DOI：
10.1007/bf02282350
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发表时间：
1996
影响因子：
3.1
通讯作者：
T. Pappas
中科院分区：
文献类型：
--
作者：
C. Mantyh;J. Maggio;P. Mantyh;S. Vigna;T. Pappas
伪膜性结肠炎最常见的原因是使用抗生素后肠道植物群过度生长后艰难梭菌分泌的毒素。在C. P物质（SP）受体拮抗剂CP-96，345可抑制艰难梭菌毒素A诱导的大鼠小肠结肠炎。为了确定SP是否在人伪膜性结肠炎的发病机制中起作用，在肠毒素A阳性标本中检查SP受体分布。定量受体放射自显影被用来检查SP受体组织从病人谁测试阳性的C。艰难毒素与对照标本相比，伪膜性结肠炎肠内小血管和淋巴聚集体中的SP受体大量增加。SP结合是可饱和的，并且对SP和CP-96，345表现出相似的亲和力。SP可能通过大量增加SP受体拮抗剂而促进伪膜性结肠炎的炎症反应，这可能为伪膜性结肠炎提供一种新的治疗干预。
Pseudomembranous colitis is most often caused by toxins secreted by Clostridium difficile following bowel flora overgrowth after antibiotic use. The secretory and inflammatory effects observed in C. difficile toxin A-induced enterocolitis in the rat ileum are inhibited by CP-96,345, a substance P (SP) receptor antagonist. To determine if SP plays a role in the pathogenesis of human pseudomembranous colitis, SP receptor distribution was examined in a toxin A-positive specimen of bowel. Quantitative receptor autoradiography was used to examine SP receptors in tissue from a patient who tested positive for C. Difficile toxin. SP receptors were massively increased in small blood vessels and lymphoid aggregates in the pseudomembranous colitis bowel in comparison to control specimens. The SP binding was saturable and exhibited similar affinities for SP and CP-96,345. SP may contribute to the inflammatory response in pseudomembranous colitis via a massive increase in SP receptor antagonists may offer a novel therapeutic intervention for pseudomembranous colitis.
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艰难梭菌毒素 A 和 B 对兔回肠的不同影响。
影响因子：
29.4
作者：
Triadafilopoulos,G;Pothoulakis,C;O'Brien,MJ;LaMont,JT
通讯作者：
LaMont,JT
克罗恩病和溃疡性结肠炎患者 P 物质受体的差异表达。
影响因子：
29.4
作者：
Mantyh,CR;Vigna,SR;Bollinger,RR;Mantyh,PW;Maggio,JE;Pappas,TN
通讯作者：
Pappas,TN
DOI：
10.1073/pnas.91.3.947
发表时间：
1994-02-01
影响因子：
11.1
作者：
POTHOULAKIS, C;CASTAGLIUOLO, I;LEEMAN, SE
通讯作者：
LEEMAN, SE
艰难梭菌毒素 A 的兔回肠受体的表征。受体偶联 G 蛋白的证据。
DOI：
10.1172/jci115267
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Pothoulakis,C;LaMont,JT;Eglow,R;Gao,N;Rubins,JB;Theoharides,TC;Dickey,BF
通讯作者：
Dickey,BF
影响因子：
15.9
作者：
KELLY, CP;BECKER, S;POTHOULAKIS, C
通讯作者：
POTHOULAKIS, C