Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders
Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders
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早期皮质发育的中断会影响大鼠的边缘关联区域和社会行为；
DOI：
10.1016/s0006-8993(99)02067-3
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发表时间：
1999
期刊：
影响因子：
2.9
通讯作者：
Jakob Korf
中科院分区：
文献类型：
--
作者：
L. Talamini;T. Koch;P. Luiten;Jaap M. Koolhaas;Jakob Korf
社会行为的缺陷在一些神经精神疾病中被发现，这些疾病被认为是发育的起源。适当的社会行为可能在很大程度上依赖于新刺激与先前存储的相关信息的联想整合。人们认为，大脑边缘的异位皮质，尤其是内嗅区域，支持这种处理过程。因此，在本研究中，在妊娠第9至12天的其中一天用甲基氧乙酸甲醇（MAM）处理妊娠坝，以中断发育中的胎儿内嗅区神经元的增殖。在成年动物中评估产前给药MAM对社会行为的影响。由于内嗅皮层在空间记忆中的作用已被一些研究所涉及，因此也对其功能的影响进行了研究。在行为研究之后，对脑形态学进行了筛选，以了解MAM的影响。我们的研究结果显示，在接受mam治疗的动物中，中度到重度的社交障碍取决于产前暴露的确切时间。相比之下，空间参考和工作记忆在任何组中都没有受到重要影响。经mam治疗的后代的脑形态学分析支持内嗅皮层发育不良，并发现一些连接边缘和边缘附属结构（如鼻周和外嗅皮层、前扣带皮层和中隔-斜带区）也出现轻度异常。研究结果讨论了关于内嗅皮质功能，以及它们与精神疾病的相关性与假定的神经发育发病机制，如精神分裂症。
Deficits in social behaviour are found in several neuropsychiatric disorders with a presumed developmental origin. Adequate social behaviour may rely importantly on the associative integration of new stimuli with previously stored, related information. The limbic allocortex, in particular the entorhinal region, is thought to support this kind of processing. Therefore, in the present study, gestating dams were treated with methylazoxymethanol acetate (MAM) on one of gestational days nine to twelve, to interrupt neuronal proliferation in the entorhinal region of the developing foetuses. Effects of prenatal MAM administration on social behaviour were evaluated in adult animals. As the entorhinal cortex has been implicated by some studies in spatial memory, effects on this function were also investigated. Following the behavioural studies, brain morphology was screened for effects of MAM. Our results show moderate to severe social impairment in MAM-treated animals, depending on the exact timing of prenatal exposure. By contrast, spatial reference and working memory were not importantly affected in any group. Analysis of brain morphology in the MAM-treated offspring supported maldevelopment of the entorhinal cortex and revealed mild abnormalities also in some connected limbic and limbic affiliated structures, such as the perirhinal and ectorhinal cortex, the anterior cingulate cortex and the medial septum-diagonal band region. Findings are discussed with respect to entorhinal cortex function, and with regard to their relevance for psychiatric disorders with a putatively neurodevelopmental pathogenesis, such as schizophrenia.
海马和嗅觉辨别学习：内嗅皮层损伤对连续提示、走不走任务中嗅觉学习和记忆的影响。
影响因子：
1.9
作者：
Otto,T;Schottler,F;Staubli,U;Eichenbaum,H;Lynch,G
通讯作者：
Lynch,G
精神分裂症患者额叶中烟酰胺腺嘌呤二核苷酸磷酸心肌黄酶细胞分布的改变意味着皮质发育的紊乱。
影响因子：
--
作者：
Akbarian,S;BunneyJr,WE;Potkin,SG;Wigal,SB;Hagman,JO;Sandman,CA;Jones,EG
通讯作者：
Jones,EG
实验诱发的脑损伤中的结构-功能关系。
影响因子：
--
作者：
Rodier,PM
通讯作者：
Rodier,PM