Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients.
Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients.
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DOI：
10.1016/j.ijid.2020.10.071
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Gille-Johnson P
中科院分区：
文献类型：
--
作者：
Tehrani S;Killander A;Åstrand P;Jakobsson J;Gille-Johnson P
本研究调查了确诊COVID-19住院患者的人口统计学、合并症和死亡率。此外，我们假设，根据临床虚弱量表（CFS），65岁或以上患者的功能状态比年龄和合并症更能预测不良结局。共有255名随机选择的COVID-19患者被纳入并随访60天。使用标准化方案从电子健康记录中手动提取患者数据。研究人群的年龄范围为20 - 103岁（平均年龄66岁± 17岁）。高血压、糖尿病和肥胖是三种最常见的合并症。在60天随访时，70例患者（27%）死亡。在多变量分析中，年龄、慢性肾病和既往中风与死亡相关。大多数致死性病例（90%）发生在65岁或以上的患者中。在这些患者中，CFS水平是多变量分析中死亡的唯一预测因素。这项研究表明，年龄增长、慢性肾脏疾病和既往卒中显著导致COVID-19住院患者的致命结局。在65岁或以上的患者中，CFS水平是死亡的最强预后因素。
This study investigated demographics, comorbidities, and death rate in hospitalized patients with confirmed COVID-19. In addition, we hypothesized that functional status, according to the Clinical Frailty Scale (CFS), in patients aged 65 years or older is a better predictor of poor outcome than age and comorbidities. A total of 255 randomly selected COVID-19 patients admitted to a university hospital were included and followed up for 60 days. Patient data were extracted manually from the electronic health records with use of a standardized protocol. The age of the study population ranged between 20 and 103 years (mean age 66 years ± 17 years). Hypertension, diabetes mellitus, and obesity were the three most prevalent comorbidities. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease, and previous stroke were associated with death. Most fatal cases (90%) occurred in patients aged 65 years or older. Among such patients, CFS level was the only predictor of death in multivariate analyses. This study shows that increasing age, chronic kidney disease, and previous stroke significantly contribute to a fatal outcome in hospitalized patients with COVID-19. In patients aged 65 years or older, CFS level was the strongest prognostic factor for death.
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DOI：
10.1590/s0036-36342012000200014
发表时间：
2012-04-01
期刊：
Salud Pública de México
影响因子：
--
作者：
Fortis, Ángeles;García-Macedo, Rebeca;Cruz, Miguel
通讯作者：
Cruz, Miguel
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
105.7
作者：
Petrilli, Christopher M.;Jones, Simon A.;Horwitz, Leora I.
通讯作者：
Horwitz, Leora I.
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
影响因子：
14.6
作者：
Rockwood, K;Song, XW;Mitnitski, A
通讯作者：
Mitnitski, A