A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin
A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin
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单次服用钠-葡萄糖协同转运蛋白-2抑制剂托格列净需要降低血浆葡萄糖水平，以增加内源性葡萄糖的产生
DOI：
10.1111/dom.14312
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Watada H
中科院分区：
文献类型：
--
作者：
Yamasaki;Tamura Y;Kaga H;Sato M;Kiya M;Kadowaki S;Suzuki R;Furukawa Y;Sugimoto D;Funayama T;Someya Y;Kakehi S;Nojiri S;Satoh H;Kawamori R;Watada H
目的：研究内源性葡萄糖生成（EGP）以及胰岛素和胰高血糖素水平的变化是否由钠-葡萄糖协同转运蛋白-2（SGLT 2）抑制剂托伐格列汀诱导的血糖（PG）水平降低引起。材料与方法：我们在12例日本2型糖尿病患者中评价了EGP，60例患者接受了未给药（CON）、SGLT 2 i托福格列汀单次给药（TOF）和TOF单次给药，并通过外源性葡萄糖输注调整PG水平，以模拟CON（TOF+ G）观察到的PG水平变化。我们评估了EGP、C肽和胰高血糖素水平从基线到给药后180分钟的变化。65结果：内源性葡萄糖生成在CON（-0.22 ± 0.11 mg/kg· min）和TOF+ G（-0.31 ± 0.24 mg/kg· min）中减少，但在TOF（+ 0.08±0.19 mg/kg· min）中不减少。C肽的下降在TOF中显著更大（-0.11至0.06 nmol/L）比CON（-0.03到0.06 nmol/L）和TOF+ G（-0.01 0. 11 nmol/L），而胰高血糖素的增加在TOF中显著更大，（+ 11.1±6.3 pmol/L），而TOF+ G（+ 8.6±7.6 pmol/L）与CON（+ 5.1±4.3 70 pmol/L）相比无显著性差异。结论：这些结果表明SGLT 2抑制剂给药诱导的PG水平降低是EGP增加和胰岛素分泌减少所必需的。
Aim: To investigate whether changes in endogenous glucose production (EGP) and insulin and glucagon levels are elicited by the decrease in plasma glucose (PG) levels induced by the sodium-glucose co-transporter-2 (SGLT2) inhibitor tofogliflozin. Materials and methods: We evaluated EGP in 12 Japanese patients with type 2 diabetes under 60 the conditions of no drugs administered (CON), single administration of the SGLT2i tofogliflozin (TOF), and single administration of TOF with adjustment of PG levels with exogenous glucose infusion to mimic changes in PG levels observed with CON (TOF+ G). We evaluated changes in EGP and levels of C-peptide and glucagon from baseline to 180 min after drug administration. 65Results: Endogenous glucose production decreased in CON (-0.22±0.11 mg/kg· min) and TOF+ G (-0.31±0.24 mg/kg· min), but not in TOF (+ 0.08±0.19 mg/kg· min). The decrease in C-peptide was significantly greater in TOF (-0.11±0.06 nmol/L) than in CON (-0.03±0.06 nmol/L) and TOF+ G (-0.01±0.11 nmol/L), while the increase in glucagon was significantly greater in TOF (+ 11.1±6.3 pmol/L) but not TOF+ G (+ 8.6±7.6 pmol/L) than in CON (+ 5.1±4.3 70 pmol/L).Conclusions: These results indicate that the decrease in PG levels induced by SGLT2 inhibitor administration is required for the increase in EGP and decrease in insulin secretion.
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胰岛素对清醒狗胰高血糖素刺激的葡萄糖产生的影响。
DOI：
10.1016/0026-0495(90)90192-f
发表时间：
1990
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
K. Steiner;P. Williams;W. Lacy;A. Cherrington
通讯作者：
A. Cherrington
影响因子：
158.5
作者：
Wiviott, S. D.;Raz, I.;Sabatine, M. S.
通讯作者：
Sabatine, M. S.
影响因子：
--
作者：
A. Cherrington;R. W. Stevenson;K. Steiner;C. C. Connolly;M. Wada;R. Goldstein
通讯作者：
R. Goldstein
DOI：
10.1152/ajpendo.00117.2003
发表时间：
2003-10-01
影响因子：
5.1
作者：
Kelley, DE;McKolanis, TM;Kalhan, SC
通讯作者：
Kalhan, SC
影响因子：
82.9
作者：
Bonner, Caroline;Kerr-Conte, Julie;Pattou, Francois
通讯作者：
Pattou, Francois