Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat
Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat
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雌性大鼠杏仁核中央催产素反应细胞群的递送依赖性转变
DOI：
10.1159/000525860
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发表时间：
2022
影响因子：
4.1
通讯作者：
Kato Fusao
中科院分区：
文献类型：
--
作者：
Suzuki Jiro;Nagase Masashi;Sato Naoko;Takahashi Yukari;Okamoto Aikou;Kato Fusao
尽管催产素（OT）最近被认为是亲社会的神经激素，但其最重要的生理作用是刺激子宫收缩。虽然众所周知，血浆OT浓度在分娩过程中会发生剧烈变化，但母体大脑中的OT受体是否以及如何被激活仍有待研究。我们研究了中央杏仁核（CeA）细胞对外源性OT类似物Thr-Gly-OT（TGOT）的反应是否随分娩而变化。分娩后24小时内（G 0）和分娩后1-3天内（G3）。比较了1 μ MTGOT、20 mM KCl（高K）和300 μM ADP对Ca 2+的反应。特别是，在G 0和G3时，响应TGOT的细胞分数（TGOT应答者）从VG和PT显著增加。G 0时，TGOT和高K反应者的TGOT与高K反应的正相关性降低，而TGOT和ADP反应者的TGOT与ADP反应的正相关性增加。结论CeA细胞对OT受体激动剂的反应在分娩前后发生了明显变化，这可能在控制分娩疼痛和产后情绪并发症中发挥作用。
IntroductionDespite its recent reputation as prosocial neurohormone, the most important physiological role of oxytocin (OT) is stimulating uterine contractions. Though it is well known that plasma OT concentrations change drastically during delivery, it remains unexplored whether and how OT receptors in the maternal brain are activated. We examined whether the responses of cells in the central amygdala (CeA), an OT receptor-rich limbic site involved in pain and fear memory regulation, to exogenously applied OT analogue, Thr-Gly-OT (TGOT), vary depending on delivery.MethodsIntracellular Ca 2+ dynamics of the CeA cells were visualized in brain slices from female rats at virgin (VG), during pregnancy term (PT) days 16–21, within 24 h after delivery (G0), and within 1–3 days after delivery (G3). The Ca 2+ responses to 1 µM TGOT, 20 mM KCl (high K), and 300 µM ADP were compared.ResultsWe found that fraction of cells responding to TGOT, high K, and ADP differed significantly between the four delivery-associated terms. In particular, the fraction of cells responding to TGOT (TGOT responders) significantly increased from VG and PT at G0 and G3. Furthermore, the significant positive correlation between TGOT and high K response in TGOT and high K responders was reduced at G0, while that between TGOT and ADP responses in TGOT and ADP responders was increased at G0.ConclusionThese results indicate that the responses of CeA cells to an OT receptor agonist markedly change around delivery, which might play a role in controlling the labor-related pain and post-delivery emotional complications.
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妊娠和分娩对人血浆和脑脊液中催产素水平的影响。
DOI：
10.1507/endocrj1954.32.875
发表时间：
1985
期刊：
Endocrinologia japonica
影响因子：
--
作者：
S. Takeda;Y. Kuwabara;M. Mizuno
通讯作者：
M. Mizuno
催产素：出生时及以后的系统评价围产期催产素的长期影响。
影响因子：
10.7
作者：
D. Monks;A. Palanisamy
通讯作者：
A. Palanisamy
勘误表：疼痛中的催产素信号传导：细胞、回路、系统和行为水平。
影响因子：
--
作者：
P. Poisbeau;V. Grinevich;A. Charlet
通讯作者：
A. Charlet
催产素与人类分娩的开始
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
P. Husslein;A. Fuchs;F. Fuchs
通讯作者：
F. Fuchs
影响因子：
16.2
作者：
Knobloch, H. Sophie;Charlet, Alexandre;Grinevicht, Valery
通讯作者：
Grinevicht, Valery