Novel targets with potential therapeutic applications in osteosarcoma.
Novel targets with potential therapeutic applications in osteosarcoma.
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DOI：
10.1007/s11912-008-0054-3
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发表时间：
2008-07
影响因子：
4.7
通讯作者：
Khanna C
中科院分区：
文献类型：
--
作者：
Khanna C
对于骨肉瘤患者，转移的发展，通常转移到肺部，是最常见的死亡原因。在过去的20年里，局部或播散性疾病患者的长期结局基本保持不变。结果的进一步改善不太可能来自细胞毒性化疗的强化;因此，需要新的治疗靶点。骨肉瘤的三个常见临床特征可以为骨肉瘤的靶点提供依据。这些包括骨肉瘤起源于骨或原始间充质细胞，以这种疾病为特征的可预测的转移进展过程，以及几乎完全在肺中发生转移性病变。某些目标与一个以上的过程相关可能是有利的。这篇综述总结了新的目标下评估的治疗骨肉瘤的基础上，这三个特点的疾病。
For patients with osteosarcoma, the development of metastases, often to the lungs, is the most common cause of death. Long-term outcomes for patients who present with localized or disseminated disease have largely remained unchanged over the past 20 years. Further improvements in outcome are not likely to come from intensification of cytotoxic chemotherapy; as such, new targets for treatment are needed. A view toward such targets in osteosarcoma may be constructed based on three common clinical features of the disease. These include the origin of osteosarcoma in the bone or primitive mesenchymal cells, the predictable process of metastatic progression characterized by this disease, and the development of metastatic lesions almost exclusively in the lung. It is likely and potentially favorable for some targets to be relevant for more than one process. This review summarizes novel targets under evaluation for the treatment of osteosarcoma based on these three features of the disease.
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影响因子：
6.1
作者：
Cunningham, Charles Casey
通讯作者：
Cunningham, Charles Casey
影响因子：
8
作者：
Corso, S.;Migliore, C.;Giordano, S.
通讯作者：
Giordano, S.
根据基因表达和骨肉瘤U2OS细胞在体外和异种移植中的生长的调节：凋亡基因作为脱甲基化的靶标。
影响因子：
5.8
作者：
Al-Romaih, Khaldoun;Somers, Gino R.;Bayani, Jane;Hughes, Simon;Prasad, Mona;Cutz, Jean-Claude;Xue, Hui;Zielenska, Maria;Wang, Yuzhuo;Squire, Jeremy A.
通讯作者：
Squire, Jeremy A.
影响因子：
3.7
作者：
Atiye, J;Wolf, M;Knuutila, S
通讯作者：
Knuutila, S
影响因子：
45.3
作者：
Harris, MB;Gieser, P;Link, MP
通讯作者：
Link, MP