Cardiac Metabolism and MiRNA Interference.
Cardiac Metabolism and MiRNA Interference.
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DOI：
10.3390/ijms24010050
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发表时间：
2022-12-20
影响因子：
5.6
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中科院分区：
文献类型：
--
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在过去的几十年中，心脏代谢疾病的异常增加引起了研究人员的注意，以探索和揭示新的机制，涉及心脏代谢疾病。近年来的研究表明，心脏能量底物代谢紊乱在慢性心脏代谢疾病的发生、发展中起着重要作用。因此，深入理解心脏代谢受损介导的疾病背后的新分子机制对于扩展治疗策略至关重要。心脏代谢的复杂和动态的途径是由新的执行者，microRNAs（miRNAs）系统地控制。miRNA通过mRNA降解或翻译抑制来调节靶基因表达，所述mRNA降解或翻译抑制通过miRNA与靶转录物之间的碱基配对来进行，分别精确地在3'种子序列和5'端的保守七段序列处进行。多种miRNA参与心脏能量底物代谢，并根据靶转录物的多样性发挥不同的作用。新的理论策略甚至已经进入治疗心脏代谢疾病的临床阶段，但实验证据仍然不足。在这篇综述中，我们确定了有效的miRNAs，其直接靶转录，并讨论了心脏代谢的重塑，以进一步的临床研究和进一步扩展新的治疗策略。本综述分为四个部分，包括（i）心脏代谢的基本机制的审查，（ii）特定的miRNA对心脏代谢途径的调节作用的披露，（iii）了解miRNA与心脏代谢受损之间的关联，和（iv）可用的miRNA靶向治疗方法的总结。
The aberrant increase in cardio-metabolic diseases over the past couple of decades has drawn researchers’ attention to explore and unveil the novel mechanisms implicated in cardiometabolic diseases. Recent evidence disclosed that the derangement of cardiac energy substrate metabolism plays a predominant role in the development and progression of chronic cardiometabolic diseases. Hence, in-depth comprehension of the novel molecular mechanisms behind impaired cardiac metabolism-mediated diseases is crucial to expand treatment strategies. The complex and dynamic pathways of cardiac metabolism are systematically controlled by the novel executor, microRNAs (miRNAs). miRNAs regulate target gene expression by either mRNA degradation or translational repression through base pairing between miRNA and the target transcript, precisely at the 3’ seed sequence and conserved heptametrical sequence in the 5’ end, respectively. Multiple miRNAs are involved throughout every cardiac energy substrate metabolism and play a differential role based on the variety of target transcripts. Novel theoretical strategies have even entered the clinical phase for treating cardiometabolic diseases, but experimental evidence remains inadequate. In this review, we identify the potent miRNAs, their direct target transcripts, and discuss the remodeling of cardiac metabolism to cast light on further clinical studies and further the expansion of novel therapeutic strategies. This review is categorized into four sections which encompass (i) a review of the fundamental mechanism of cardiac metabolism, (ii) a divulgence of the regulatory role of specific miRNAs on cardiac metabolic pathways, (iii) an understanding of the association between miRNA and impaired cardiac metabolism, and (iv) summary of available miRNA targeting therapeutic approaches.
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影响因子：
3.7
作者：
Bartman CM;Oyama Y;Brodsky K;Khailova L;Walker L;Koeppen M;Eckle T
通讯作者：
Eckle T
影响因子：
4.6
作者：
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2.6
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影响因子：
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通讯作者：
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影响因子：
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Chang, Jinhong;Nicolas, Emmanuelle;Taylor, John M
通讯作者：
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