Spleen contraction elevates hemoglobin concentration at high altitude during rest and exercise.
Spleen contraction elevates hemoglobin concentration at high altitude during rest and exercise.
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DOI：
10.1007/s00421-020-04471-w
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发表时间：
2020-12
影响因子：
3
通讯作者：
Lodin-Sundström A
中科院分区：
文献类型：
--
作者：
Schagatay E;Lunde A;Nilsson S;Palm O;Lodin-Sundström A
已知缺氧和运动分别触发脾脏收缩，导致储存的红细胞释放。我们研究了脾脏体积和血红蛋白浓度（Hb）在休息和运动在三个海拔高度。11名健康的低地人在海拔1370、3700和4200 m进行了5 min的改良哈佛台阶试验。通过超声成像和毛细血管Hb测量脾脏体积，在休息期间和台阶试验后，动脉血氧饱和度（SaO 2），心率（HR），呼气CO2（ETCO 2）和呼吸频率（RR）在整个测试。静息脾体积随海拔升高而减少，在所有海拔进行运动后进一步减少。在1370 m处的平均（SE）基线脾脏体积为252（20）mL，运动后为199（15）mL（P < 0.01）。在3700 m时，基线脾脏体积为231（22）mL，运动后为166（12）mL（P < 0.05）。在4200米时，基线容量为210（23）mL，运动后为172（20）mL（P < 0.05）。10分钟后，脾脏体积增加到基线在所有海拔（NS）。基线Hb随海拔升高而升高，从1370 m时的138.9（6.1）g/L增加到3700 m时的141.2（4.1）g/L和4200 m时的152.4（4.0）g/L（P < 0.01）。在所有海拔高度，Hb在运动期间从基线增加到1370 m处的146.8（5.7）g/L，3700 m处的150.4（3.8）g/L和4200 m处的157.3（3.8）g/L（均为P < 0.05）。在所有海拔高度（NS）休息10分钟后，Hb恢复至基线水平。4200 m时脾源性Hb升高幅度小于3700 m（P < 0.05）。在休息和运动期间，呼吸变量也受到海拔高度的影响。在高海拔地区，脾脏在休息时收缩并动员储存的红细胞，在运动时进一步收缩，以增加急性缺氧时向组织输送的氧气。在最高海拔地区，Hb对运动的反应减弱，可能是由于在休息时脾脏储备的招募增加，并且在运动时达到最大脾脏收缩。
Hypoxia and exercise are known to separately trigger spleen contraction, leading to release of stored erythrocytes. We studied spleen volume and hemoglobin concentration (Hb) during rest and exercise at three altitudes. Eleven healthy lowlanders did a 5-min modified Harvard step test at 1370, 3700 and 4200 m altitude. Spleen volume was measured via ultrasonic imaging and capillary Hb with Hemocue during rest and after the step test, and arterial oxygen saturation (SaO2), heart rate (HR), expiratory CO2 (ETCO2) and respiratory rate (RR) across the test. Resting spleen volume was reduced with increasing altitude and further reduced with exercise at all altitudes. Mean (SE) baseline spleen volume at 1370 m was 252 (20) mL and after exercise, it was 199 (15) mL (P < 0.01). At 3700 m, baseline spleen volume was 231 (22) mL and after exercise 166 (12) mL (P < 0.05). At 4200 m baseline volume was 210 (23) mL and after exercise 172 (20) mL (P < 0.05). After 10 min, spleen volume increased to baseline at all altitudes (NS). Baseline Hb increased with altitude from 138.9 (6.1) g/L at 1370 m, to 141.2 (4.1) at 3700 m and 152.4 (4.0) at 4200 m (P < 0.01). At all altitudes Hb increased from baseline during exercise to 146.8 (5.7) g/L at 1370 m, 150.4 (3.8) g/L at 3700 m and 157.3 (3.8) g/L at 4200 m (all P < 0.05 from baseline). Hb had returned to baseline after 10 min rest at all altitudes (NS). The spleen-derived Hb elevation during exercise was smaller at 4200 m compared to 3700 m (P < 0.05). Cardiorespiratory variables were also affected by altitude during both rest and exercise. The spleen contracts and mobilizes stored red blood cells during rest at high altitude and contracts further during exercise, to increase oxygen delivery to tissues during acute hypoxia. The attenuated Hb response to exercise at the highest altitude is likely due to the greater recruitment of the spleen reserve during rest, and that maximal spleen contraction is reached with exercise.
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影响因子：
3.3
作者：
Kuwahira, I;Kamiya, U;Gonzalez, NC
通讯作者：
Gonzalez, NC
影响因子：
3.3
作者：
HURFORD, WE;HONG, SK;ZAPOL, WM
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ZAPOL, WM
影响因子：
3.3
作者：
LAUB, M;HVIDJACOBSEN, K;NIELSEN, SL
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影响因子：
3
作者：
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Reimers, J
影响因子：
3
作者：
Richardson, Matt X.;de Bruijn, Robert;Schagatay, Erika
通讯作者：
Schagatay, Erika