Millimeter-Sized Suspended Plasmonic Nanohole Arrays for Surface-Tension-Driven Flow-Through SERS.
Millimeter-Sized Suspended Plasmonic Nanohole Arrays for Surface-Tension-Driven Flow-Through SERS.
复制标题
毫米大小的悬浮等离子体纳米荷尔阵列，用于表面张力驱动的流动sers。
DOI：
10.1021/cm5031848
复制
发表时间：
2014-11-25
影响因子：
8.6
通讯作者：
Oh, Sang-Hyun
中科院分区：
文献类型：
--
作者：
Kumar, Shailabh;Cherukulappurath, Sudhir;Johnson, Timothy W.;Oh, Sang-Hyun
我们提出了金属纳米孔阵列制造在悬浮膜作为光流体衬底。采用纳米压印技术制备了毫米级悬浮纳米孔阵列。我们展示了基于折射率的光谱调整，使用蔗糖溶液优化SERS信号强度，导致拉曼增强因子为107。此外，与死端纳米孔阵列相比，能够通过流动检测的悬浮纳米孔阵列将测量到的SERS信号强度提高了50倍。对于分析物的定向输运，我们提出了一种新的方法，利用表面张力产生流过纳米孔的自发流动，流速为1 μL/min，从而避免了外部泵或微流体互连的需要。使用该方法检测SERS，我们获得了比扩散限制传输高50倍的信号，并且可以检测100 pM的4-巯基吡啶。本文提出的悬浮纳米孔衬底具有均匀和可重复的几何形状，并显示出改进分析物传输和SERS检测的潜力。
We present metallic nanohole arrays fabricated on suspended membranes as an optofluidic substrate. Millimeter-sized suspended nanohole arrays were fabricated using nanoimprint lithography. We demonstrate refractive-index-based tuning of the optical spectra using a sucrose solution for the optimization of SERS signal intensity, leading to a Raman enhancement factor of 107. Furthermore, compared to dead-ended nanohole arrays, suspended nanohole arrays capable of flow-through detection increased the measured SERS signal intensity by 50 times. For directed transport of analytes, we present a novel methodology utilizing surface tension to generate spontaneous flow through the nanoholes with flow rates of 1 μL/min, obviating the need for external pumps or microfluidic interconnects. Using this method for SERS, we obtained a 50 times higher signal as compared to diffusion-limited transport and could detect 100 pM 4-mercaptopyridine. The suspended nanohole substrates presented herein possess a uniform and reproducible geometry and show the potential for improved analyte transport and SERS detection.
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