Antigen-induced immunomodulation in the pathogenesis of atherosclerosis.
Antigen-induced immunomodulation in the pathogenesis of atherosclerosis.
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DOI：
10.1155/2008/723539
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发表时间：
2008
影响因子：
--
通讯作者：
Oviedo-Orta E
中科院分区：
文献类型：
--
作者：
Milioti N;Bermudez-Fajardo A;Penichet ML;Oviedo-Orta E
动脉粥样硬化是一种慢性炎症性疾病，其特征是单核细胞/巨噬细胞、平滑肌细胞和淋巴细胞响应促炎分子的释放而在动脉壁内积聚。这种积累导致动脉粥样硬化斑块的形成，最终会演变成全动脉闭塞、破裂、钙化或动脉瘤等并发症。尽管动脉粥样硬化形成的分子机制尚不完全清楚，但很明显，免疫系统在动脉粥样硬化斑块的形成及其并发症中起着关键作用。有多种抗原刺激与动脉粥样硬化的发病机制相关。这些刺激大部分来自修饰的自身分子，如氧化低密度脂蛋白 (oxLDL)、β2 糖蛋白 1 (β2GP1)、脂蛋白 a (LP(a))、热休克蛋白 (HSP) 以及细胞外基质的蛋白质成分，如晚期糖基化终末 (AGE) 产物形式的胶原蛋白和纤维蛋白原。此外，一些外来抗原，包括牙龈卟啉单胞菌和肺炎衣原体等细菌以及肠道病毒和巨细胞病毒等病毒，作为潜在的致病因素或旁观者与动脉粥样硬化相关，这为动脉粥样硬化的病理生理学分析增加了另一层复杂性。本综述总结了过去二十年发表的关于抗原、抗原刺激和适应性免疫反应在动脉粥样硬化斑块形成中的重要性的最重要的科学发现。
Atherosclerosis is a chronic inflammatory disorder characterised by the accumulation of monocytes/macrophages, smooth muscle cells, and lymphocytes within the arterial wall in response to the release of proinflammatory molecules. Such accumulation results in the formation of the atherosclerotic plaque, which would eventually evolve to complications such as total artery occlusion, rupture, calcification, or aneurysm. Although the molecular mechanism responsible for the development of atherosclerosis is not completely understood, it is clear that the immune system plays a key role in the development of the atherosclerotic plaque and in its complications. There are multiple antigenic stimuli that have been associated with the pathogenesis of atherosclerosis. Most of these stimuli come from modified self-molecules such as oxidised low-density lipoproteins (oxLDLs), beta2glycoprotein1 (β2GP1), lipoprotein a (LP(a)), heat shock proteins (HSPs), and protein components of the extracellular matrix such as collagen and fibrinogen in the form of advanced glycation-end (AGE) products. In addition, several foreign antigens including bacteria such as Porphyromonas gingivalis and Chlamydia pneumoniae and viruses such as enterovirus and cytomegalovirus have been associated with atherosclerosis as potentially causative or bystander participants, adding another level of complexity to the analysis of the pathophysiology of atherosclerosis. The present review summarises the most important scientific findings published within the last two decades on the importance of antigens, antigen stimulation, and adaptive immune responses in the development of atherosclerotic plaques.
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DOI：
10.1161/01.atv.11.5.1223
发表时间：
1991-09-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
AMENTO, EP;EHSANI, N;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
168.9
作者：
Bason, C;Corrocher, R;Puccetti, A
通讯作者：
Puccetti, A
急性冠脉综合征患者Th17/Treg失衡
影响因子：
8.6
作者：
Cheng, Xiang;Yu, Xian;Liao, Yu-hua
通讯作者：
Liao, Yu-hua
影响因子：
4.3
作者：
Cassar, K;Bachoo, P;Brittenden, J
通讯作者：
Brittenden, J
DOI：
10.1073/pnas.94.9.4642
发表时间：
1997-04-29
影响因子：
11.1
作者：
Dansky, HM;Charlton, SA;Smith, JD
通讯作者：
Smith, JD