Vascular rhythms and adaptation: do your arteries know what time it is?
Vascular rhythms and adaptation: do your arteries know what time it is?
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血管节律和适应：你的动脉知道现在是什么时间吗？
DOI：
10.1161/circulationaha.108.847798
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发表时间：
2009
期刊：
影响因子：
37.8
通讯作者：
Weaver,DavidR
中科院分区：
文献类型：
--
作者：
KeaneyJr,JohnF;Weaver,DavidR
心血管疾病的临床表现并非在一天中随机发生的观点已被接受了 40 年。记录胸痛发作时间的队列研究表明，早晨更容易出现心肌梗塞。 1 然而，当时很难将早晨起床时心肌梗塞发病率的上升与醒来时长期存在的夜间症状区分开来。随着限制心肌梗塞面积的研究的出现，通过循环肌酸激酶水平的时间依赖性增加来准确识别心肌梗塞的发作成为可能，并且这些数据证实了大约在早上 6 点到中午之间的几个小时内达到峰值的分布。 2 很快我们就发现，根据 Muller 的研究，心血管疾病的其他表现，例如心源性猝死、中风和心肌缺血，都表现出类似的时间依赖性。 3 如果纠正睡眠停止时间的个体差异，则大多数事件发生在醒来后的前 3 小时内。 4
The notion that the clinical manifestations of cardiovas-cular disease do not occur randomly throughout the course of the day has been accepted for 4 decades. Cohort studies documenting the time of chest pain onset demonstrated a morning predilection for the presentation of myocardial infarction. 1 At the time, however, it was difficult to discern a morning rise in the incidence of myocardial infarction from the simple realization of longstanding nocturnal symptoms on awakening. With the advent of studies to limit myocardial infarct size, it became possible to accurately identify the myocardial infarction onset by the timedependent increase in circulating creatine kinase levels, and these data confirmed a distribution roughly peaking in the hours between 6 AM and noon. 2 It soon became clear that other manifestations of cardiovascular disease, such as sudden cardiac death, stroke, and myocardial ischemia all exhibited similar time-of-day dependence, as reviewed by Muller. 3 If one corrects for individual variations in the time of sleep cessation, the preponderance of events occur within the first 3 hours after awakening. 4
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影响因子：
15.9
作者：
Rudic, RD;Shesely, EG;Sessa, WC
通讯作者：
Sessa, WC
影响因子：
15.9
作者：
Shiojima, I;Sato, K;Walsh, K
通讯作者：
Walsh, K
影响因子：
3.5
作者：
Stratmann, Markus;Schibler, Ueli
通讯作者：
Schibler, Ueli
影响因子：
56.9
作者：
VITATERNA, MH;KING, DP;TAKAHASHI, JS
通讯作者：
TAKAHASHI, JS
DOI：
10.1111/j.1749-6632.1984.tb23452.x
发表时间：
1984-01-01
影响因子：
5.2
作者：
ASCHOFF, J
通讯作者：
ASCHOFF, J