Disorders of Vascular Permeability.
Disorders of Vascular Permeability.
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DOI：
10.1146/annurev-pathol-012615-044506
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发表时间：
2016-05-23
期刊：
影响因子：
--
通讯作者：
D'Amore PA
中科院分区：
文献类型：
--
作者：
Park-Windhol C;D'Amore PA
内皮屏障维持血管和组织的动态平衡，调节许多生理过程，如血管生成。血管屏障的完整性可被多种可溶性通透性因子破坏，而屏障功能的改变可在疾病进展过程中加剧组织损伤。了解内皮屏障功能对血管内稳态至关重要。许多促进血管通透性的信号通路也可以在疾病期间被触发，导致长时间或不受控制的血管渗漏。人们认为，要恢复正常的血管系统，就需要减少这种高渗透状态。尽管在过去的几十年里已经对血管渗漏的分子机制进行了研究，但最近的进展已经确定了新的治疗靶点，已经开始显示出临床前和临床前景。这些方法已经成功地应用于越来越多的疾病。关于血管渗漏如何影响各种疾病的进展，在这篇综述中强调了新的观点。
The endothelial barrier maintains vascular and tissue homeostasis and modulates many physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted by a variety of soluble permeability factors, and changes in barrier function can exacerbate tissue damage during disease progression. Understanding endothelial barrier function is critical for vascular homeostasis. Many of the signaling pathways promoting vascular permeability can also be triggered during disease, resulting in prolonged or uncontrolled vascular leak. It is believed that recovery of the normal vasculature requires diminishing this hyperpermeable state. Although the molecular mechanisms governing vascular leak have been studied over the last few decades, recent advances have identified new therapeutic targets that have begun to show preclinical and clinical promise. These approaches have been successfully applied to an increasing number of disease conditions. New perspectives regarding how vascular leak impacts the progression of various diseases are highlighted in this review.
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DOI：
10.1083/jcb.200907135
发表时间：
2010-03-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cain RJ;Vanhaesebroeck B;Ridley AJ
通讯作者：
Ridley AJ
影响因子：
--
作者：
ABELL, RG
通讯作者：
ABELL, RG
DOI：
10.1152/ajpheart.00542.2005
发表时间：
2006-01-01
影响因子：
4.8
作者：
Baffert, F;Le, T;McDonald, DM
通讯作者：
McDonald, DM
影响因子：
3.3
作者：
Chiasson, Christine M.;Wittich, Kristin B.;Kowalczyk, Andrew P.
通讯作者：
Kowalczyk, Andrew P.
影响因子：
--
作者：
Clark, ER;Clark, EL
通讯作者：
Clark, EL