A Clinical Association between an Increasing Renal Resistive Index and the Atherosclerotic Burden in Patients with a Preserved Renal Function
A Clinical Association between an Increasing Renal Resistive Index and the Atherosclerotic Burden in Patients with a Preserved Renal Function
复制标题
肾功能保留患者肾阻力指数增加与动脉粥样硬化负担之间的临床关联
DOI：
10.2169/internalmedicine.3232-19
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发表时间：
2020
影响因子：
1.2
通讯作者：
T. Ikeda
中科院分区：
文献类型：
--
作者：
I. Watanabe;Y. Shintani;Shigenori Terada;T. Fujii;Shunsuke Kiuchi;R. Nakanishi;T. Katayanagi;Muneyasu Kawasaki;K. Tokuhiro;H. Ohsawa;T. Ikeda
目的肾功能损害的进展与心血管疾病风险的增加呈正相关。我们的目的是检查肾阻力指数（RRI）之间的关系，通过双功超声评估和动脉粥样硬化的程度，在没有肾损害的患者进行血管成像研究。方法对106例肾小球滤过率（eGFR）≥60 mL/min/1.73 m2的门诊患者行冠状动脉CT血管造影（CCTA），术前评估RRI。在这些受试者中，还进行了颈动脉超声扫描以评估颈动脉疾病。结果31例患者存在多部位动脉粥样硬化（CAC>0，cIMT ≥ 1.0mm），其中31例患者的冠状动脉钙化（CAC）>0，cIMT≥ 1.0mm。随着动脉粥样硬化血管数量的增加，RRI显著增加（无动脉粥样硬化：0.65±0.04 vs.单部位动脉粥样硬化：0.67±0.06 vs.多部位动脉粥样硬化：0.71±0.05，p<0.001）。多因素Logistic回归分析显示RRI>0.70 [比值比（OR）：4.05，95%可信区间（CI），1.37-12.0，p=0.01]，心踝血管指数（CAVI）≥9.0（OR：8.18，95% CI：2.47-27.1，p<0.01），糖尿病（OR：4.34，95% CI：1.37-13.7，p=0.01）和eGFR>90 mL/min/1.73 m2（OR：5.89，95% CI：1.39-25.1，p=0.01）与多部位动脉粥样硬化相关。结论RRI是无肾功能损害患者动脉粥样硬化的亚临床指标。
Objective A positive correlation is observed between the progression of renal impairment and the increasing risk of cardiovascular disease. Our aim was to examine the relationship between the renal resistive index (RRI) assessed by duplex sonography and the extent of atherosclerosis in patients without renal impairment undergoing vascular imaging studies. Methods The RRI was evaluated pre-procedurally among 106 outpatients with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 undergoing clinically-driven coronary computed tomography angiography (CCTA). In those subjects, a carotid artery ultrasound scan was also performed to evaluate carotid artery disease. We investigated the association between the RRI and the atherosclerotic extent, defined by the presence of coronary artery calcium (CAC)>0 and carotid intima-media thickness (cIMT)≥1.0 mm. Results Multi-site atherosclerosis (CAC>0 and cIMT≥1.0 mm) was found in 31 patients. The RRI was significantly increased with an increasing number of atherosclerotic vessels (absence of atherosclerosis: 0.65±0.04 vs. single-site atherosclerosis: 0.67±0.06 vs. multi-site atherosclerosis: 0.71±0.05, p<0.001). A multivariate logistic regression analysis showed that RRI>0.70 [odds ratio (OR): 4.05, 95% confidence interval (CI), 1.37-12.0, p=0.01], cardio ankle vascular index (CAVI)≥9.0 (OR: 8.18, 95% CI: 2.47-27.1, p<0.01), diabetes (OR: 4.34, 95% CI: 1.37-13.7, p=0.01) and an eGFR>90 mL/min/1.73 m2 (OR: 5.89, 95% CI: 1.39-25.1, p=0.01) were associated with multi-site atherosclerosis. Conclusion The RRI, a sub-clinical renal parameter is an atherosclerotic marker in patients without renal impairment.
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
DOI：
10.1053/j.ajkd.2009.10.044
发表时间：
2010-02
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Pearce JD;Craven TE;Edwards MS;Corriere MA;Crutchley TA;Fleming SH;Hansen KJ
通讯作者：
Hansen KJ
影响因子：
2.4
作者：
Kumar, Ujjala;Wettersten, Nicholas;Garimella, Pranav S.
通讯作者：
Garimella, Pranav S.