Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study.
Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study.
复制标题
高血压患者低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率和甘油三酯对糖尿病的贡献和相互作用：一项横断面研究。
DOI：
10.1111/jdi.12856
复制
发表时间：
2019-01
影响因子：
3.2
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Hong M;Ling Y;Lu Z;Liu Y;Gu P;Shao J;Gao X;Li X
高血压是糖尿病最重要的危险因素之一。本研究旨在探讨高血压患者的血脂谱（包括低密度脂蛋白胆固醇（LDL-C）与高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平的比值）与2型糖尿病的相关性及其相互作用。2014年至2016年，在复旦大学附属中山医院（中国上海）高血压门诊连续入组了无糖尿病和降血脂药病史的高血压患者。收集一般临床数据，包括体重指数、血压、空腹血糖和负荷后2小时血糖水平以及血脂谱。分别计算LDL-C/HDL-C比值、TG/HDL-C比值和TC/HDL-C比值。采用SPSS 13.0软件进行统计学分析。共纳入935例高血压患者，其中114例（12.2%）诊断为糖尿病。经过多变量调整后，LDL-C/HDL-C比值和TG水平与糖尿病的相关性最显著和独立。在多变量logistic回归分析中，LDL-C/HDL-C比值和TG与糖尿病独立相关。纳入相互作用变量后，LDL-C/HDL-C比率仍然与糖尿病独立相关，但TG被TG* LDL-C/HDL-C取代。总之，在高血压患者中，LDL-C/HDL-C比值和TG水平升高与糖尿病相关，在高血压人群中，LDL-C/HDL-C比值和TG对糖尿病具有交互作用。
Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate the associations of lipid profiles, including the ratio of low‐density lipoprotein cholesterol (LDL‐C)‐to‐high‐density lipoprotein cholesterol (HDL‐C) and triglyceride (TG) levels, as well as their interactions, with type 2 diabetes in hypertensive patients. Hypertensive patients without a history of diabetes and hypolipidemic agents were enrolled continuously at the Hypertension Clinic, Zhongshan Hospital, Fudan University (Shanghai, China) from 2014 to 2016. General clinical data, including body mass index, blood pressure, fasting glucose and 2‐h post‐load glucose levels, and lipid profiles, were collected. The LDL‐C/HDL‐C ratio, TG/HDL‐C ratio and TC/HDL‐C ratio were separately calculated. Statistical analyses were carried out by using SPSS software (version 13.0). In total, 935 hypertensive patients were included, of which 114 patients (12.2%) were diagnosed with diabetes. After multivariate adjustments, the LDL‐C/HDL‐C ratio and TG levels had the most significant and independent associations with diabetes. In the multivariate logistic regression, the LDL‐C/HDL‐C ratio and TG were independently associated with diabetes. After the interaction variable was included, the LDL‐C/HDL‐C ratio remained independently associated with diabetes, but TG was replaced by TG*LDL‐C/HDL‐C. In conclusion, elevated LDL‐C/HDL‐C ratios and TG levels were associated with diabetes in patients with hypertension, with an interactive effect of the LDL‐C/HDL‐C ratio and TG on diabetes in the hypertensive population.
登录
查看更多内容
影响因子：
9.3
作者：
Sung KC;Park HY;Kim MJ;Reaven G
通讯作者：
Reaven G
影响因子：
5.1
作者：
Puavilai, G;Chanprasertyotin, S;Sriphrapradaeng, A
通讯作者：
Sriphrapradaeng, A
影响因子：
8.3
作者：
Alderman, MH;Cohen, H;Madhavan, S
通讯作者：
Madhavan, S
影响因子：
8.3
作者：
Mancia, Giuseppe;Bombelli, Michele;Sega, Roberto
通讯作者：
Sega, Roberto
影响因子：
7.7
作者：
Hao, Mingming;Head, W. Steven;Piston, David W.
通讯作者：
Piston, David W.