The Future of Bioorthogonal Chemistry.
The Future of Bioorthogonal Chemistry.
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DOI：
10.1021/acscentsci.8b00251
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发表时间：
2018-08-22
影响因子：
18.2
通讯作者：
Devaraj NK
中科院分区：
文献类型：
--
作者：
Devaraj NK
生物正交反应已广泛用于从聚糖工程到体内成像的应用中。研究人员已经设计了许多可以在生物环境中预测的反应。根据预期应用的要求，可以很容易地部署来自可用工具包的一个或多个反应。随着越来越多的研究人员在生命系统中探索和应用化学反应，很明显，该领域可能会有无数的发展方式。本文对生物正交化学的发展前景进行了展望。我讨论目前出现的机会，并推测如何生物正交反应可能会应用于研究和翻译设置。我还概述了如果要朝着这些目标取得进展，必须清除的障碍。鉴于生物正交化学过去令人难以置信的成功和该领域创新的快速发展，未来无疑是非常光明的。生物正交反应在化学生物学中有着广泛的应用。本文简要展望了该领域的未来，概述了新兴领域和需要克服的主要挑战。
Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous reactions that can be predictably performed in a biological setting. Depending on the requirements of the intended application, one or more reactions from the available toolkit can be readily deployed. As an increasing number of investigators explore and apply chemical reactions in living systems, it is clear that there are a myriad of ways in which the field may advance. This article presents an outlook on the future of bioorthogonal chemistry. I discuss currently emerging opportunities and speculate on how bioorthogonal reactions might be applied in research and translational settings. I also outline hurdles that must be cleared if progress toward these goals is to be made. Given the incredible past successes of bioorthogonal chemistry and the rapid pace of innovations in the field, the future is undoubtedly very bright. Bioorthogonal reactions have found widespread use in chemical biology. This article gives a brief outlook on the future of the field, outlining emerging areas and key challenges to overcome.
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DOI：
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发表时间：
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影响因子：
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