Psychotherapy as monotherapy for the treatment of bipolar II depression: a proof of concept study.
Psychotherapy as monotherapy for the treatment of bipolar II depression: a proof of concept study.
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DOI：
10.1111/j.1399-5618.2008.00629.x
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发表时间：
2009-02
影响因子：
5.4
通讯作者：
Houck P
中科院分区：
文献类型：
--
作者：
Swartz HA;Frank E;Frankel DR;Novick D;Houck P
我们进行了一项概念验证研究，以确定使用个体心理治疗，人际和社会节律治疗（IPSRT），作为双相II型抑郁症的急性治疗的单药治疗的可行性。符合DSM-IV双相II型障碍标准且目前抑郁的未用药个体（n = 17）接受每周心理治疗（IPSRT），持续12周。在12周的急性治疗后，个体接受额外的8周随访治疗，包括持续每周一次的IPSRT和IPSRT无应答者的补充拉莫三嗪。到第12周，41%（n = 7）的样本对IPSRT单药治疗有反应（定义为抑郁评分降低≥50%而躁狂评分未增加），41%（n = 7）退出或从研究中移除，18%（n = 3）对治疗无反应。到第20周，53%（n = 9）的患者达到缓解，29%（n = 5）的患者症状完全缓解。人际和社会节律疗法似乎是一个有前途的干预与双相II型抑郁症的个人子集。需要一项随机对照试验来系统评价IPSRT作为双相II型抑郁症急性单药治疗的疗效。
We conducted a proof of concept study to determine the feasibility of using an individual psychotherapy, Interpersonal and Social Rhythm Therapy (IPSRT), as monotherapy for the acute treatment of bipolar II depression. Unmedicated individuals (n = 17) meeting DSM-IV criteria for bipolar II disorder and currently depressed received weekly psychotherapy (IPSRT) for 12 weeks. After 12 weeks of acute treatment, individuals received an additional 8 weeks of follow-up treatment consisting of continued weekly IPSRT with supplementary lamotrogine for IPSRT non-responders. By week 12, 41% (n = 7) of the sample responded to IPSRT monotherapy (defined as ≥50% reduction in depression scores without an increase in mania scores), 41% (n = 7) dropped out of or were removed from the study, and 18% (n = 3) did not respond to treatment. By week 20, 53% (n = 9) had achieved a response and 29% (n = 5) achieved a full remission of symptoms. Interpersonal and Social Rhythm Therapy appears to be a promising intervention for a subset of individuals with bipolar II depression. A randomized controlled trial is needed to systematically evaluate the efficacy of IPSRT as an acute monotherapy for bipolar II depression.
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