Soluble Guanylyl Cyclase and Platelet Function a
Soluble Guanylyl Cyclase and Platelet Function a
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可溶性鸟苷酸环化酶和血小板功能a
DOI：
10.1111/j.1749-6632.1994.tb12039.x
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发表时间：
1994
影响因子：
5.2
通讯作者：
R. Gerzer
中科院分区：
文献类型：
--
作者：
K. Ivanova;W. Buechler;G. Wolfram;C. Drummer;J. Heim;R. Gerzer
可溶性鸟苷酸环化酶大量存在于血小板中。这种异二聚体血红素蛋白被一氧化氮（NO）激活，并参与NO对血小板功能的抑制作用。NO干扰血小板活化的早期步骤，包括钙动员和抑制粘附和聚集。NO由内皮细胞和多种其他细胞类型内源性形成。通常用于治疗心绞痛的硝基血管扩张剂也通过释放NO起作用。这些药物释放NO是酶偶联的，并且只有少量NO从这些药物自发释放。血小板不含从有机硝酸盐中释放NO的酶系统。因此，这些药物在体外只能微弱地激活血小板可溶性鸟苷酸环化酶并抑制血小板活化。然而，NO在血管中从这些药物中释放，并且可以到达体内靠近血管壁的血小板。因此，这些药物在心肌梗死一级或二级预防中的许多作用可能来自其抗血小板作用，而不是来自其扩张血管的能力。可溶性鸟苷酸环化酶被激活的机制的知识，大大有助于我们了解血小板功能的调节机制，并提出了新的治疗可能性。
Soluble guanylyl cyclase is abundantly present in platelets. This heterodimeric heme-protein is activated by nitric oxide (NO) and is involved in the inhibitory action of NO on platelet function. NO interferes with early steps of platelet activation involving calcium mobilization and inhibits both adhesion and aggregation. NO is formed endogenously from endothelium and a variety of other cell types. The nitrovasodilators, commonly used for the treatment of angina pectoris, also act through the release of NO. The release of NO from these drugs is enzyme coupled, and only a little NO is released from these drugs spontaneously. Platelets do not contain the enzyme system(s) that releases NO from organic nitrates. These drugs can therefore only weakly activate platelet-soluble guanylyl cyclase and inhibit platelet activation in vitro. However, NO is released from these drugs in the vessels and can reach the platelets close to the vessel wall in vivo. Therefore, many effects of these drugs in the primary or secondary prevention of myocardial infarction might come from their antiplatelet action rather than from their ability to dilate vessels. Knowledge of the mechanisms by which soluble guanylyl cyclase is activated has contributed considerably to our understanding of the mechanisms of regulation of platelet function and has presented us with new therapeutic possibilities.
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鉴定牛冠状平滑肌细胞中硝酸甘油代谢为一氧化氮的亚细胞位点。
DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Chung,SJ;Fung,HL
通讯作者：
Fung,HL
影响因子：
56.9
作者：
VERMA, A;HIRSCH, DJ;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
15.9
作者：
MURAD, F
通讯作者：
MURAD, F
DOI：
10.1016/s0021-9258(17)38380-1
发表时间：
1986-06
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Y. Kamisaki;S. Saheki;M. Nakane;J. Palmieri;T. Kuno;B. Chang;S. Waldman;F. Murad
通讯作者：
Y. Kamisaki;S. Saheki;M. Nakane;J. Palmieri;T. Kuno;B. Chang;S. Waldman;F. Murad
编码来自大鼠肺的 70 千道尔顿可溶性鸟苷酸环化酶亚基的 cDNA 的分子克隆。
DOI：
10.1016/s0006-291x(88)80992-6
发表时间：
1988
影响因子：
3.1
作者：
Nakane,M;Saheki,S;Kuno,T;Ishii,K;Murad,F
通讯作者：
Murad,F