Protein Expression of bax, bcl-2, and p53 in Patients with Non-Hodgkin's Gastric Lymphoma: Prognostic Significance
Protein Expression of bax, bcl-2, and p53 in Patients with Non-Hodgkin's Gastric Lymphoma: Prognostic Significance
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非霍奇金胃淋巴瘤患者中 bax、bcl-2 和 p53 的蛋白表达：预后意义
DOI：
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发表时间：
2000
影响因子：
2.6
通讯作者：
G. Androulakis
中科院分区：
文献类型：
--
作者：
G. Charalambous;I. Gomatos;M. Konstadoulakis;E. Messaris;A. Manouras;A. Apostolou;E. Leandros;M. Karayannis;G. Androulakis
摘要。bcl-2、bax和p53基因表达在非霍奇金胃淋巴瘤患者中的生物学意义尚不清楚。我们在1990年至1995年间对36例胃淋巴瘤患者进行了这些基因的预后价值检测。采用免疫组织化学方法对36例胃淋巴瘤患者行胃初级切除术的石蜡包埋标本进行p53、bax和bcl-2基因表达分析。36例肿瘤中有24例（66.7%）表达bax， 8例（22.2%）表达p53, 6例（16.7%）检测到bcl-2细胞质染色。我们进行了单变量分析，以检查这些基因的表达与患者生存之间可能存在的相关性。bax蛋白的表达是有统计学意义的预后因素（p= 0.049）。p53和bcl-2蛋白表达与生存率无统计学相关性。在bcl-2阴性（−）患者组（30例）中，bax阳性患者的生存率明显高于bax阴性患者（63.3%比36.7%,p= 0.03）。p53的表达与肿瘤的分级也有统计学意义（p= 0.0014）。P53蛋白表达随分级升高。bax的表达是影响胃淋巴瘤患者预后的重要因素。在bcl-2阴性患者中，其预后价值显著增加；但bax的表达不能作为独立的预后因素。bcl-2和p53的表达无预后意义。p53的表达似乎代表了分化丧失的标志。
Abstract. The biologic significance of bcl-2, bax, and p53 gene expression in patients with non-Hodgkin's gastric lymphoma is unknown. We examined the prognostic value of these genes in 36 patients with gastric lymphoma treated in our clinic between 1990 and 1995. Paraffin-embedded specimens from 36 patients who underwent primary resection of the stomach for gastric lymphoma were analyzed immunohistochemically for p53, bax, and bcl-2 gene expression. Expression of bax was seen in 24 of 36 patients (66.7%), p53 expression was found in 8 of 36 tumors (22.2%), and bcl-2 cytoplasmic staining was detected in 6 of 36 patients (16.7%). We performed a univariate analysis to examine the possible correlation between the expression of these genes and the survival of our patients. Expression of bax protein proved to be a statistically significant prognostic factor (p= 0.049). Protein expression of p53 and bcl-2 did not statistically correlate with survival. In the bcl-2-negative (−) patient group (30 patients), those who were bax-positive had a statistically significant better survival than those who were bax-negative (63.3% vs. 36.7%, p= 0.03). There was also a statistically significant correlation between p53 expression and the grade of the tumor (p= 0.0014). P53 protein expression increased along with the grade. Expression of bax is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in bcl-2-negative patients; but expression of bax failed to be an independent prognostic factor. Expression of bcl-2 and p53 has no prognostic significance. Expression of p53 seems to represent a marker for loss of differentiation.
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IE 和 IIE 期胃非霍奇金淋巴瘤的胃保留。
DOI：
10.1200/jco.1990.8.2.266
发表时间：
1990
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Maor,MH;Velasquez,WS;Fuller,LM;Silvermintz,KB
通讯作者：
Silvermintz,KB
影响因子：
56.9
作者：
TSUJIMOTO, Y;COSSMAN, J;CROCE, CM
通讯作者：
CROCE, CM
DOI：
10.1073/pnas.82.21.7439
发表时间：
1985-01-01
影响因子：
11.1
作者：
CLEARY, ML;SKLAR, J
通讯作者：
SKLAR, J
高水平的 p53 蛋白表达与间变性大细胞淋巴瘤中的 p53 基因突变无关。
DOI：
--
发表时间：
1993
期刊：
The American journal of pathology
影响因子：
--
作者：
Cesarman,E;Inghirami,G;Chadburn,A;Knowles,DM
通讯作者：
Knowles,DM
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC