Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.
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DOI：
10.4049/jimmunol.1003865
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发表时间：
2011-05-15
期刊：
影响因子：
--
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Norling LV;Spite M;Yang R;Flower RJ;Perretti M;Serhan CN
对自限性炎症过程中的内源性微粒(MPS)进行了系统的分析。利用基于LC-MS/MS的代谢组学方法，从炎性渗出物的MPS中鉴定出专门化促分解脂质介体(LM)的前体。因此，我们推测，抗炎和促进分解的LM的形成可能是MPS的有益作用的基础，这一过程可以作为生物仿生的基础。利用人中性粒细胞来源的MPS，我们构建了含有阿司匹林触发的解决素D1(AT-RvD1)或脂氧素A4(LXA4)类似物的新型纳米颗粒(NPs)。浓缩的NPs显著减少了PMN在小鼠腹膜炎中的流入，缩短了消退间隔，并显示出促进角质形成细胞愈合的促消解作用。富含的NPs可以保护TMJ免受炎症的侵袭。这些发现表明，人源化纳米粒，称为纳米前分解药物(NPRMs)，模拟内源性分解机制，具有强大的有益生物活性，可以降低纳米毒性，并提供新的治疗方法。
Endogenous microparticles (MPs) were systematically profiled during the time course of self-limited inflammation. Precursors for specialized pro-resolving lipid mediators (LM) were identified in MPs from inflammatory exudates utilizing LC-MS/MS-based metabolomics. Hence, we postulated that formation of anti-inflammatory and pro-resolving LM could underlie beneficial effects attributed to MPs and that this process could serve as a basis for biomimicry. Using human neutrophil-derived MPs, we constructed novel nanoparticles (NPs) containing aspirin-triggered resolvin D1 (AT-RvD1) or a lipoxin A4 (LXA4) analog. Enriched NPs dramatically reduced PMN influx in murine peritonitis, shortened resolution intervals and exhibited pro-resolving actions accelerating keratinocyte healing. The enriched NPs protected against inflammation in the temporomandibular joint (TMJ). These findings indicate that humanized NPs, termed nano-pro-resolving medicines (NPRMs) are mimetics of endogenous resolving mechanisms, possess potent beneficial bioactions, can reduce nanotoxicity and offer new therapeutic approaches.
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影响因子：
2.9
作者：
Kramer, Phillip R.;Kerins, Carolyn A.;Bellinger, Larry L.
通讯作者：
Bellinger, Larry L.
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1016/j.plefa.2009.09.004
发表时间：
2009-11
期刊：
Prostaglandins, leukotrienes, and essential fatty acids
影响因子：
--
作者：
Sun YP;Tjonahen E;Keledjian R;Zhu M;Yang R;Recchiuti A;Pillai PS;Petasis NA;Serhan CN
通讯作者：
Serhan CN
影响因子：
20.3
作者：
Dalli, Jesmond;Norling, Lucy V.;Perretti, Mauro
通讯作者：
Perretti, Mauro
影响因子：
15.3
作者：
Serhan, Charles N.;Yang, Rong;Martinod, Kimberly;Kasuga, Kie;Pillai, Padmini S.;Porter, Timothy F.;Oh, Sungwhan F.;Spite, Matthew
通讯作者：
Spite, Matthew