Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
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DOI：
10.1242/dev.098418
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Reiprich S
中科院分区：
文献类型：
--
作者：
Hoffmann SA;Hos D;Küspert M;Lang RA;Lovell-Badge R;Wegner M;Reiprich S
脑室区的神经前体细胞产生中枢神经系统的所有神经元和神经胶质，并依赖于密切相关的SoxB1转录因子Sox1、Sox2和Sox3来维持其前体特征。我们发现，在小鼠脊髓，而SoxB1蛋白通常下调后，神经元的规格，他们继续在胶质细胞前体表达。在少突胶质细胞谱系中，Sox 2和Sox 3仍然存在于终末分化的早期阶段。令人惊讶的是，它们的缺失不会改变前体特征，但会干扰适当的分化。虽然对髓鞘基因表达的直接影响可能是其功能的一部分，但我们提供了另一种作用模式的证据。SoxB1蛋白通过负控制miR145促进少突胶质细胞分化，从而防止这种microRNA抑制几种促分化因子。这项研究提出了为数不多的情况下，其中SoxB1蛋白，包括干细胞因子Sox2，与分化，而不是前体功能。
Neural precursor cells of the ventricular zone give rise to all neurons and glia of the central nervous system and rely for maintenance of their precursor characteristics on the closely related SoxB1 transcription factors Sox1, Sox2 and Sox3. We show in mouse spinal cord that, whereas SoxB1 proteins are usually downregulated upon neuronal specification, they continue to be expressed in glial precursors. In the oligodendrocyte lineage, Sox2 and Sox3 remain present into the early phases of terminal differentiation. Surprisingly, their deletion does not alter precursor characteristics but interferes with proper differentiation. Although a direct influence on myelin gene expression may be part of their function, we provide evidence for another mode of action. SoxB1 proteins promote oligodendrocyte differentiation in part by negatively controlling miR145 and thereby preventing this microRNA from inhibiting several pro-differentiation factors. This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions.
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