The vascular niche in next generation microphysiological systems.
The vascular niche in next generation microphysiological systems.
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DOI：
10.1039/d1lc00530h
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发表时间：
2021-09-07
期刊：
影响因子：
6.1
通讯作者：
Hughes CCW
中科院分区：
文献类型：
--
作者：
Ewald ML;Chen YH;Lee AP;Hughes CCW
近年来，微生理系统（MPS，也称为器官芯片或组织芯片）平台的出现，极大地提高了临床前建模的预测能力，从而降低了药物进入试验时的高损耗率。虽然它们的设计可以有很大的不同，但一般来说，MPS是生物工程化的体外微环境，概括了人体器官的关键功能单元，并在人体生理学，病理生理学和临床药理学中具有广泛的应用。MPS器械发展的关键下一步是在组织内广泛纳入功能性血管系统。脉管系统本身是一个主要器官，它将营养物质、免疫细胞、信号分子和治疗药物运送到所有其他器官。它还在通过表达血管分泌因子诱导和维持组织特性，以及在提供组织特异性环境（即，血管生态位），可以支持干细胞的存活和功能。因此，器官由脉管系统形成图案、维持和支持，脉管系统又接收驱动组织特异性基因表达的信号。在这篇综述中，我们将讨论已发表的血管化MPS平台，并提出希望纳入这一关键成分的下一代器械的考虑因素。最后，我们将强调由脉管系统控制的器官形成过程，以及如何在MPS平台内纳入血管生态位将为研究干细胞发育提供独特的机会。
In recent years, microphysiological system (MPS, also known as, organ-on-a-chip or tissue chip) platforms have emerged with great promise to improve the predictive capacity of preclinical modeling thereby reducing the high attrition rates when drugs move into trials. While their designs can vary quite significantly, in general MPS are bioengineered in vitro microenvironments that recapitulate key functional units of human organs, and that have broad applications in human physiology, pathophysiology, and clinical pharmacology. A critical next step in the evolution of MPS devices is the widespread incorporation of functional vasculature within tissues. The vasculature itself is a major organ that carries nutrients, immune cells, signaling molecules and therapeutics to all other organs. It also plays critical roles in inducing and maintaining tissue identity through expression of angiocrine factors, and in providing tissue-specific milieus (i.e., the vascular niche) that can support the survival and function of stem cells. Thus, organs are patterned, maintained and supported by the vasculature, which in turn receives signals that drive tissue specific gene expression. In this review, we will discuss published vascularized MPS platforms and present considerations for next-generation devices looking to incorporate this critical constituent. Finally, we will highlight the organ-patterning processes governed by the vasculature, and how the incorporation of a vascular niche within MPS platforms will establish a unique opportunity to study stem cell development.
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影响因子：
10
作者：
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