Punctate white matter lesions in infants: new insights using susceptibility-weighted imaging.
Punctate white matter lesions in infants: new insights using susceptibility-weighted imaging.
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DOI：
10.1007/s00234-011-0872-0
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发表时间：
2011-09
期刊：
影响因子：
2.8
通讯作者：
Groenendaal, Floris
中科院分区：
文献类型：
--
作者：
Niwa, Tetsu;de Vries, Linda S.;Benders, Manon J. N. L.;Takahara, Taro;Nikkels, Peter G. J.;Groenendaal, Floris
点状白质病变 (PWML) 通过磁共振成像 (MRI) 识别为 T1 加权成像上的高信号和 T2 加权成像上的低信号。我们的目的是使用磁敏感加权成像 (SWI) 评估 PWML 中出现出血成分的频率。其中包括 17 名患有 PWML 的早产儿（胎龄为 25-34 周）和 7 名足月婴儿（MRI 年龄为 37-42 周）。七名早产儿接受了连续 MRI 检查。 PWML 通过传统 MRI 进行诊断，并与 SWI 进行比较，SWI 信号丢失提示出血。考虑到相关脑部病变的模式，并计算每个婴儿 SWI 信号丢失的病变百分比。与主要诊断为脑白质损伤的婴儿（n = 14；中位数为14.2%；p< 0.01）相比，主要诊断为生发基质和脑室内出血的婴儿（n = 8）的SWI信号丢失百分比（中位数为93.9%）显着更高。在进行连续 MRI 的婴儿中，在足月等效年龄时注意到 PWML 数量和/或 SWI 信号丢失的减少。在死亡的患者中，组织学证实了与出血和神经胶质增生相关的囊性病变。 SWI 可以区分出血性和非出血性 PWML。当 PWML 与脑室内出血相关时，SWI 信号丢失更为常见。纵向成像显示 PWML 的数量随着时间的推移而减少，一些 PWML 在 SWI 上不再显示信号丢失，表明早期神经胶质增生。本文的在线版本 (doi:10.1007/s00234-011-0872-0) 包含补充材料，可供授权用户使用。
Punctate white matter lesions (PWML) are recognized with magnetic resonance imaging (MRI) as hypersignal on T1-weighted imaging and hyposignal on T2-weighted imaging. Our aim was to assess how often a hemorrhagic component was present in PWML using susceptibility-weighted imaging (SWI). Seventeen preterm (gestational age, 25–34 weeks) and seven full-term infants (age at MRI, 37–42 weeks) with PWML were included. Seven preterm infants had sequential MRIs. PWML were diagnosed with conventional MRI and compared with SWI, where signal loss is suggestive of hemorrhage. The pattern of associated brain lesions was taken into account, and the percentage of lesions with signal loss on SWI was calculated for each infant. A significantly higher percentage of signal loss on SWI (median, 93.9%) was found among infants with germinal matrix and intraventricular hemorrhage as the primary diagnosis (n = 8) compared to those with a primary diagnosis of white matter injury (n = 14; median, 14.2%; p < 0.01). In the infants with serial MRIs, a reduction in the number of PWML and/or signal loss on SWI was noted at term equivalent age. In the patient who died, cystic lesions, associated with hemorrhage and gliosis, were demonstrated on histology. SWI can distinguish hemorrhagic and non-hemorrhagic PWML. Signal loss on SWI was more common when PWML were associated with an intraventricular hemorrhage. Longitudinal imaging showed a decrease in the number of PWML over time, with some PWML no longer showing signal loss on SWI, suggesting early gliosis. The online version of this article (doi:10.1007/s00234-011-0872-0) contains supplementary material, which is available to authorized users.
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影响因子：
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作者：
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