Peptidergic innervation of the vasoconstrictor muscle of the abdominal aorta in Aplysia kurodai
Peptidergic innervation of the vasoconstrictor muscle of the abdominal aorta in Aplysia kurodai
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海兔腹主动脉缩血管肌的肽能神经支配
DOI：
10.1242/jeb.01273
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发表时间：
2004
影响因子：
2.8
通讯作者：
Y. Furukawa
中科院分区：
文献类型：
--
作者：
K. Sasaki;F. Morishita;Y. Furukawa
摘要海洋软体动物Aaprosia的动脉系统由三条主要动脉组成。其中之一，腹主动脉，在动脉的底部有一个括约肌（血管收缩肌）。这种肌肉的收缩减少了流入腹主动脉的血液，从而在调节血液分布中发挥作用。在这里，我们表明血管收缩肌的收缩性是由三种类型的内源性肽，贻贝抑制肽相关肽（AMRP），肠溶蛋白和NdWFamide调制。免疫组化显示，含有这三种肽的假定神经元过程存在于血管收缩肌中。肠溶素抑制神经刺激或应用一种假定的兴奋性递质乙酰胆碱（ACh）引起的肌肉收缩。肠溶蛋白使肌肉静息电位超极化，并降低兴奋性接点电位（EJP）的振幅。AMRP也抑制神经诱发的收缩，虽然它对乙酰胆碱引起的收缩的作用是可变的。AMRP还减少了EJP的大小，但对肌肉的静息电位没有影响。NdWFamide增强神经诱发的收缩，但不增强ACh诱发的收缩。NdWFamide增强EJP而不影响肌肉的静息电位。这些结果表明，AMRP，肠溶素和NdWFamide是内源性调节剂的收缩活动的血管收缩肌肉，和肽能神经支配的肌肉有助于微调的血液分布在Aaplasia。
SUMMARY The arterial system of the marine mollusc Aplysia consists of three major arteries. One of them, the abdominal aorta, has a sphincter (the vasoconstrictor muscle) at the base of the artery. Contraction of this muscle reduces the blood flow into the abdominal aorta, thereby, playing a role in the regulation of the blood distribution in Aplysia. Here, we show the contractility of the vasoconstrictor muscle is modulated by three types of endogenous peptides, Aplysia mytilus inhibitory peptide-related peptides (AMRP), enterin and NdWFamide. Immunohistochemistry showed that putative neuronal processes containing the three peptides exist in the vasoconstrictor muscle. Enterin inhibited the muscle contraction elicited by the nerve stimulation or the application of a putative excitatory transmitter, acetylcholine (ACh). Enterin hyperpolarized the resting potential of the muscle and decreased the amplitude of the excitatory junction potential (EJP). AMRP also inhibited the nerve-evoked contraction although its action on the ACh-induced contraction was variable. AMRP also reduced the size of EJP, but had no effect on the resting potential of the muscle. NdWFamide enhanced the nerve-evoked contraction but not the ACh-induced contraction. NdWFamide augmented EJP without affecting the resting potential of the muscle. These results suggest that AMRP, enterin and NdWFamide are endogenous modulators of the contractile activity of the vasoconstrictor muscle, and that the peptidergic innervations of this muscle contribute to fine tuning of the blood distribution in Aplysia.
DOI：
10.1152/jappl.1990.68.1.241
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Norton,KI;Jones,MT;Armstrong,RB
通讯作者：
Armstrong,RB
海兔食物唤醒对心血管影响的神经元介导。
影响因子：
2.5
作者：
Koch,UT;Koester,J;Weiss,KR
通讯作者：
Weiss,KR