Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.
Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.
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DOI：
10.1002/pros.20891
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发表时间：
2009-03-01
期刊：
影响因子：
2.8
通讯作者：
Cooney, Kathleen A.
中科院分区：
文献类型：
--
作者：
Lange, Ethan M.;Beebe-Dimmer, Jennifer L.;Ray, Anna M.;Zuhlke, Kimberly A.;Ellis, Jaclyn;Wang, Yunfei;Walters, Sarah;Cooney, Kathleen A.
前列腺癌连锁研究已被用来定位罕见的和可能高度渗透的癌症易感基因。潜在的遗传异质性，以及疾病的高散发性背景，导致许多信号在研究研究之间往往是不可重复的。我们对参加密歇根大学前列腺癌遗传学项目（PCGP）的131个高加索人前列腺癌家族进行了基于SNP的全基因组连锁扫描。最强的连锁证据在16q23（LOD = 2.70在rs1079635）。前列腺癌与16q23相同区域的连锁已被其他人观察到，该区域包含几个强候选基因，包括已知的前列腺癌肿瘤抑制基因ATBF 1和WWOX。在我们之前对175个PCGP家族的连锁研究中没有检测到这种连锁信号，说明了前列腺癌易感性的遗传异质性。进一步的连锁研究结合来自连锁家族的肿瘤分析正在进行中，以确定推定的遗传性前列腺癌基因16q23。
Prostate cancer linkage studies have been used to localize rare and presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity, as well as the high sporadic background of the disease, has resulted in many signals that are often not reproducible between research studies. We conducted a SNP-based genome wide linkage scan on 131 Caucasian prostate cancer families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP). The strongest evidence for linkage was detected at 16q23 (LOD = 2.70 at rs1079635). Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX. This linkage signal was not detected in our prior linkage study on 175 PCGP families, illustrating the genetic heterogeneity underlying prostate cancer susceptibility. Further linkage studies in combination with tumor analyses from linked families are in progress to identify the putative hereditary prostate cancer gene at 16q23.
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