Control networks and hubs.

Control networks and hubs.
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DOI:
10.1111/psyp.13032
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发表时间:
2018-03
期刊:
影响因子:
3.7
通讯作者:
Petersen SE
Petersen SE
中科院分区:
心理学3区
文献类型:
--
作者:
Gratton C;Sun H;Petersen SE

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执行控制功能与通过分布式大规模网络相互作用的额叶、顶叶、扣带和岛状脑区有关。在这里,我们讨论fMRI功能连接如何揭示控制网络的组织以及它们如何与大脑的其他部分相互作用。在我们综述的第一部分,我们从fMRI功能连通性、激活和病变研究中提出了趋同的证据,表明大脑中存在多个具有不同功能特性的可分离控制网络。在第二部分中,我们讨论了图论概念如何帮助阐明控制网络与其他大脑区域相互作用以执行目标导向功能的机制,重点是专门的中枢区域在调解跨网络相互作用方面的作用。再一次,我们结合了功能连接、损伤和任务激活研究来支持这一说法。我们的结论是,大规模网络视角为执行控制的神经基础提供了重要的神经生物学约束,这将指导未来执行功能及其在疾病中的破坏的基础和转化研究。
Executive control functions are associated with frontal, parietal, cingulate, and insular brain regions that interact through distributed large-scale networks. Here, we discuss how fMRI functional connectivity can shed light on the organization of control networks and how they interact with other parts of the brain. In the first section of our review, we present convergent evidence from fMRI functional connectivity, activation, and lesion studies that there are multiple dissociable control networks in the brain with distinct functional properties. In the second section, we discuss how graph theoretical concepts can help illuminate the mechanisms by which control networks interact with other brain regions to carry out goal-directed functions, focusing on the role of specialized hub regions for mediating cross-network interactions. Again, we use a combination of functional connectivity, lesion, and task activation studies to bolster this claim. We conclude that a large-scale network perspective provides important neurobiological constraints on the neural underpinnings of executive control, which will guide future basic and translational research into executive function and its disruption in disease.
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