The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy.
The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy.
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DOI：
10.18632/oncotarget.18297
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发表时间：
2017-11-10
期刊：
影响因子：
--
通讯作者：
Hamaguchi T
中科院分区：
文献类型：
--
作者：
Shoji H;Tada K;Kitano S;Nishimura T;Shimada Y;Nagashima K;Aoki K;Hiraoka N;Honma Y;Iwasa S;Takashima A;Kato K;Boku N;Honda K;Yamada T;Heike Y;Hamaguchi T
晚期胃癌（AGC）患者外周血免疫状态的预后意义尚不清楚。从2013年7月到2014年12月，37名患者入组。在有25个免疫细胞亚群的患者中，粒细胞髓源性抑制细胞（Gr-MDSCs）高组患者的无进展生存期（PFS）明显短于低组患者(3.98个月vs 8.78个月；P = 0.01)。在多变量分析中，高Gr-MDSCs值也与较短的PFS相关(HR, 4.60； 95%可信区间（CI）， 1.79−11.8；P = 0.001)。虽然在单因素分析中未发现显著性差异，但在多因素分析中，高Gr-MDSCs组与较短的总生存期（OS）相关（HR, 2.89; 95% CI, 1.23-6.80; p = 0.015）。在这项探索性前瞻性研究中，AGC患者在开始一线顺铂化疗（S-1 +顺铂或S-1 +顺铂+多西紫杉醇）前采集外周血样本。用多色流式细胞术分析外周血单个核细胞25个免疫亚群。根据每个免疫细胞亚群的中位数，将患者分为高组和低组（分别为≥和<中位数），比较PFS和OS。Gr-MDSCs的外周免疫状态似乎影响AGC的预后。需要进一步的研究来证实循环Gr-MDSCs水平作为AGC预后和/或预测指标的临床价值。
The prognostic significance of peripheral immune status in patients with advanced gastric cancer (AGC) remains unclear. From July 2013 through December 2014, 37 patients were enrolled. Among patients with 25 subsets of immune cells, patients in the high group of granulocytic myeloid-derived suppressor cells (Gr-MDSCs) showed significantly shorter progression-free survival (PFS) than those in the low group (3.98 vs. 8.78 months; hazards ratio (HR), 2.61; p = 0.01). In multivariate analysis, the high Gr-MDSCs value was also associated with shorter PFS (HR, 4.60; 95% confidence interval (CI), 1.79−11.8; p = 0.001). Although significant difference was not found in univariate analysis, the high Gr-MDSCs group was associated with shorter overall survival (OS) (HR, 2.89; 95% CI, 1.23–6.80; p = 0.015) in multivariate analysis. In this explorative prospective study, peripheral blood samples were collected from AGC patients before initiating first-line cisplatin-based chemotherapy (S-1 + cisplatin or S-1 + cisplatin + docetaxel). Peripheral blood mononuclear cells were analyzed for 25 immune subsets by multicolor flow cytometry. PFS and OS were compared between the patients divided into high and low (≥ and < median, respectively) groups based on the median value for each immune cell subset. The peripheral immune status of Gr-MDSCs appears to affect the prognosis in AGC. Further research is needed to confirm the clinical value of the level of circulating Gr-MDSCs as a prognostic and/or predictive marker in AGC.
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影响因子：
3.6
作者：
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发表时间：
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发表时间：
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影响因子：
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影响因子：
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