Frequent and prolonged shedding of bocavirus in young children attending daycare.
Frequent and prolonged shedding of bocavirus in young children attending daycare.
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DOI：
10.1086/652405
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Englund JA
中科院分区：
文献类型：
--
作者：
Martin ET;Fairchok MP;Kuypers J;Magaret A;Zerr DM;Wald A;Englund JA
背景。关于人类bobov （HBoV）的持久性和脱落以及HBoV检测与呼吸道症状的发生和消退之间的关系，人们知之甚少。方法。我们对119名日托儿童呼吸道疾病的前瞻性纵向研究鼻拭子样本进行HBoV检测。结果。70名儿童（59%）和318例病例中的106例（33%）检出HBoV。106例hbov阳性病例中有76例（72%）检出另一种病毒。观察到延长和间歇性脱落，长达75天的HBoV检测记录一致。在45个无症状入组样本中，有20个（44%）检测到HBoV，入组时有症状儿童和无症状儿童的HBoV患病率和病毒载量没有显著差异。HBoV阳性疾病比HBoV阴性疾病的持续时间更长（症状持续时间的比值比为70天，2.44；95%可信区间为1.41-4.22），HBoV载量≥4 log10拷贝/mL的疾病比HBoV阴性疾病需要就诊的次数更多（比值比为1.64；95%可信区间为1.02-2.64）。结论。HBoV在严重疾病中更为常见。然而，在这项对日托中心的婴幼儿进行的前瞻性研究中，HBoV的检测与呼吸道疾病的存在或特定呼吸道症状无关。
Background. Little is known about human bocavirus (HBoV) persistence and shedding and the association between HBoV detection and the onset and resolution of respiratory symptoms. Methods. We performed HBoV testing on nasal swab samples from a prospective, longitudinal study of respiratory illness in 119 children who attended daycare. Results. HBoV was detected in 70 children (59%) and in 106 (33%) of the 318 cases of illness. Another virus was detected in 76 (72%) of 106 HBoV-positive cases. Extended and intermittent shedding was observed, with consistent HBoV detection documented for up to 75 days. HBoV was detected in 20 (44%) of 45 asymptomatic enrollment samples, and HBoV prevalence and viral load did not differ significantly between children with and children without symptoms at enrollment. HBoV-positive illnesses were longer than HBoV-negative illnesses (odds ratio for duration of symptoms >7 days, 2.44; 95% confidence interval, 1.41–4.22), and illnesses with HBoV load ≥4 log10 copies/mL required a visit to a health care provider more often than did HBoV-negative illnesses (odds ratio, 1.64; 95% confidence interval, 1.02–2.64). Conclusion. HBoV was more common in illnesses with greater severity. However, detection of HBoV was not associated with the presence of respiratory illness or with specific respiratory symptoms in this prospective study of infants and toddlers attending daycare centers.
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DOI：
10.1016/j.jcv.2004.03.018
发表时间：
2004-10
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Morrow R
通讯作者：
Morrow R
DOI：
10.1016/j.jcv.2004.11.023
发表时间：
2005-08
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Corey L;Morrow R
通讯作者：
Morrow R
影响因子：
9.4
作者：
Kuypers, Jane;Wright, Nancy;Morrow, Rhoda
通讯作者：
Morrow, Rhoda
影响因子：
11.8
作者：
Longtin J;Bastien M;Gilca R;Leblanc E;de Serres G;Bergeron MG;Boivin G
通讯作者：
Boivin G
DOI：
10.1016/j.jcv.2008.05.010
发表时间：
2008-10
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Jacques J;Moret H;Renois F;Lévêque N;Motte J;Andréoletti L
通讯作者：
Andréoletti L