Selective vulnerability of hippocampal interneurons to graded traumatic brain injury.
Selective vulnerability of hippocampal interneurons to graded traumatic brain injury.
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DOI：
10.1016/j.nbd.2018.07.022
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发表时间：
2019-09
影响因子：
6.1
通讯作者：
Hunt RF
中科院分区：
文献类型：
--
作者：
Frankowski JC;Kim YJ;Hunt RF
创伤性脑损伤是许多长期心理健康问题的主要危险因素。虽然潜在的机制可能涉及受损的抑制，很少有人知道个别亚群的interneurons是如何受到神经创伤。在这里，我们报告了长期损失的海马中间神经元后，控制性皮质撞击（CCI）损伤的成年小鼠，局灶性皮质挫伤损伤的模型在人类。脑损伤的小鼠在0.5 mm和1.0 mm的撞击深度后30天显示中间神经元的子区域和细胞类型特异性减少，并且增加撞击深度导致更大的细胞损失。在一般情况下，我们发现一个优先减少的interneuron队列位于主细胞和多晶型层，而细胞类型定位在分子层似乎保存完好。我们的研究结果表明，脑挫伤后中间神经元多样性的急剧变化可能有助于创伤性脑损伤的病理生理学。
Traumatic brain injury is a major risk factor for many long-term mental health problems. Although underlying mechanisms likely involve compromised inhibition, little is known about how individual subpopulations of interneurons are affected by neurotrauma. Here we report long-term loss of hippocampal interneurons following controlled cortical impact (CCI) injury in young-adult mice, a model of focal cortical contusion injury in humans. Brain injured mice displayed subfield and cell-type specific decreases in interneurons 30 days after impact depths of 0.5 mm and 1.0 mm, and increasing the depth of impact led to greater cell loss. In general, we found a preferential reduction of interneuron cohorts located in principal cell and polymorph layers, while cell types positioned in the molecular layer appeared well preserved. Our results suggest a dramatic shift of interneuron diversity following contusion injury that may contribute to the pathophysiology of traumatic brain injury.
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DOI：
10.1523/jneurosci.0032-11.2011
发表时间：
2011-05-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hunt RF;Scheff SW;Smith BN
通讯作者：
Smith BN
影响因子：
4.7
作者：
Liepert, J;Storch, P;Weiller, C
通讯作者：
Weiller, C
影响因子：
4.6
作者：
Dinday MT;Girskis KM;Lee S;Baraban SC;Hunt RF
通讯作者：
Hunt RF
影响因子：
5.3
作者：
Gupta, Akshay;Elgammal, Fatima S.;Santhakumar, Vijayalakshmi
通讯作者：
Santhakumar, Vijayalakshmi
影响因子：
4.2
作者：
Hall, Edward D.;Bryant, Ying Deng;Sullivan, Patrick G.
通讯作者：
Sullivan, Patrick G.