Muscle does not drive persistent posttraumatic elbow contracture in a rat model.
Muscle does not drive persistent posttraumatic elbow contracture in a rat model.
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DOI：
10.1002/mus.26344
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发表时间：
2018-12
期刊：
影响因子：
3.4
通讯作者：
Lake SP
中科院分区：
文献类型：
--
作者：
Dunham CL;Chamberlain AM;Meyer GA;Lake SP
Post-traumatic elbow contracture is clinically challenging because injury often disrupts multiple periarticular soft tissues. Tissue specific contribution to contracture, particularly muscle, remains poorly understood. This study utilized a previously developed animal model of elbow contracture. After surgically inducing a unilateral soft tissue injury, injured limbs were immobilized for 3, 7, 21, and 42 days (IM) or for 42 IM with 42 days of free mobilization (42/42 IM-FM). Biceps brachii active/passive mechanics and morphology were evaluated at 42 IM and 42/42 IM-FM, while biceps brachii and brachialis gene expression was evaluated at all time points. Injured limb muscle exhibited significantly altered active/passive mechanics and decreased fiber area at 42 IM but returned to control levels by 42/42 IM-FM. Gene expression suggested muscle growth rather than a fibrotic response at 42/42 IM-FM. Muscle is a transient contributor to motion loss in our rat model of post-traumatic elbow contracture.
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影响因子：
5.5
作者：
Meyer, Gretchen A.;Lieber, Richard L.
通讯作者：
Lieber, Richard L.
影响因子：
2.4
作者：
Murray, WM;Buchanan, TS;Delp, SL
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Delp, SL
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作者：
Rooney SI;Tobias JW;Bhatt PR;Kuntz AF;Soslowsky LJ
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Soslowsky LJ
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通讯作者：
Muehleman, Carol