Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect.
Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect.
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DOI：
10.1089/neur.2021.0055
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发表时间：
2022
影响因子：
2.4
通讯作者：
Grau JW
中科院分区：
文献类型：
--
作者：
Baine RE;Johnston DT;Strain MM;Henwood MK;Davis JA;Reynolds JA;Giles ED;Grau JW
脊髓损伤（SCI）通常是创伤性事故的结果，也会产生多种其他损伤（多发性创伤）。来自相关损伤的伤害性输入已被证明显著损害SCI后的恢复。从历史上看，我们实验室的工作只集中在雄性动物身上;然而，女性SCI发病率的增加需要研究来确定疼痛（伤害性）输入是否对她们的恢复造成同样的风险。一些动物研究表明，女性表现出更大的组织保护和更好的运动恢复后SCI。鉴于此，我们在两种疼痛模型中研究了性别对SCI恢复的影响-对尾部进行间歇性电刺激（电击）或对后爪注射辣椒素。雌性大鼠接受下胸部挫伤，并在第二天暴露于伤害性刺激。评估伤害性输入对心血管功能、运动能力和出血的急性影响。用辣椒素或有害电刺激治疗扰乱了运动表现，增加了血压，并扰乱了步进。其他实验研究了有害输入的长期后果，表明有害电刺激和辣椒素都会损害雌性大鼠的长期恢复。有趣的是，当孕激素和雌激素水平较低时（动情后期），损伤对行为表现的影响更大。相反，伤害性输入导致更大的破坏运动性能，并产生了更大的上升，在发情期受伤的动物的血压。
Spinal cord injuries (SCIs) are often the result of traumatic accidents, which also produce multiple other injuries (polytrauma). Nociceptive input from associated injuries has been shown to significantly impair recovery post-SCI. Historically, work in our laboratory has focused exclusively on male animals; however, increasing incidence of SCI in females requires research to determine whether pain (nociceptive) input poses the same risk to their recovery. Some animal studies have shown that females demonstrate greater tissue preservation and better locomotor recovery post-SCI. Given this, we examined the effect of sex on SCI recovery in two pain models—intermittent electrical stimulation (shock) to the tail or capsaicin injection to the hindpaw. Female rats received a lower thoracic contusion injury and were exposed to noxious stimulation the next day. The acute effect of noxious input on cardiovascular function, locomotor performance, and hemorrhage were assessed. Treatment with capsaicin or noxious electrical stimulation disrupted locomotor performance, increased blood pressure, and disrupted stepping. Additional experiments examined the long-term consequences of noxious input, demonstrating that both noxious electrical stimulation and capsaicin impair long-term recovery in female rats. Interestingly, injury had a greater effect on behavioral performance when progesterone and estrogen were low (metestrus). Conversely, nociceptive input led to a greater disruption in locomotor performance and produced a greater rise in blood pressure in animals injured during estrus.
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影响因子：
3.4
作者：
Hauben, E;Mizrahi, T;Schwartz, M
通讯作者：
Schwartz, M
影响因子：
3
作者：
Fauss GNK;Strain MM;Huang YJ;Reynolds JA;Davis JA;Henwood MK;West CR;Grau JW
通讯作者：
Grau JW
影响因子：
2.7
作者：
Grau JW;Huang YJ
通讯作者：
Huang YJ
影响因子：
4.2
作者：
Datto, Jeffrey P.;Bastidas, Johana C.;Pearse, Damien D.
通讯作者：
Pearse, Damien D.
影响因子：
2.7
作者：
Hook, Michelle A.;Liu, Grace T.;Grau, James W.
通讯作者：
Grau, James W.