Quantitative Genetics of Response to Novelty and Other Stimuli by Infant Rhesus Macaques (Macaca mulatta) Across Three Behavioral Assessments.
Quantitative Genetics of Response to Novelty and Other Stimuli by Infant Rhesus Macaques (Macaca mulatta) Across Three Behavioral Assessments.
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DOI：
10.1007/s10764-014-9750-z
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发表时间：
2014-02-01
影响因子：
2.5
通讯作者：
Rogers, J.
中科院分区：
文献类型：
--
作者：
Fawcett, G. L.;Dettmer, A. M.;Kay, D.;Raveendran, M.;Higley, J. D.;Ryan, N. D.;Cameron, J. L.;Rogers, J.
灵长类动物的行为在发育过程中受到遗传因素和环境经验的影响。以往的研究恒河猴（Macaca mulatta）研究的遗传变异表达的行为和相关的神经生物学性状（遗传和/或遗传关联）的影响，使用各种研究设计。大多数这些先前的研究检查了遗传对成年或青少年恒河猴行为的影响，而不是在发育早期的年轻猕猴中。为了评估婴儿行为反应性和对新奇事物的反应的环境和加性遗传变异，我们调查了俄勒冈州国家灵长类动物研究中心（ONPRC）大量（N = 428）出生并安置在大型户外围栏中的纯种婴儿的一系列行为特征。我们在一系列简短的测试中记录了每个受试者的行为，包括每个婴儿暴露在一个新的环境中，在没有母亲在场的情况下暴露在社会威胁中，以及在母亲在场但被镇静的情况下暴露在一个新的环境中。我们发现，愿意离开母亲，探索新的环境（h2 = 0.25 ± 0.13; P = 0.003）的显着遗传力（h2）。当母亲不在时，婴儿对分离应激或威胁也表现出一系列可遗传的行为反应（h2 = 0.23 ± 0.13-0.24 ± 0.15，P < 0.01）。我们没有观察到母亲的环境对这些特征的影响的证据。我们的研究结果扩展了非人灵长类动物的气质和反应性的遗传影响的知识，通过证明婴儿恒河猴的行为反应性的几个措施是可遗传的。
Primate behavior is influenced by both heritable factors and environmental experience during development. Previous studies of rhesus macaques (Macaca mulatta) examined the effects of genetic variation on expressed behavior and related neurobiological traits (heritability and/or genetic association) using a variety of study designs. Most of these prior studies examined genetic effects on the behavior of adults or adolescent rhesus macaques, not in young macaques early in development. To assess environmental and additive genetic variation in behavioral reactivity and response to novelty among infants, we investigated a range of behavioral traits in a large number (N = 428) of pedigreed infants born and housed in large outdoor corrals at the Oregon National Primate Research Center (ONPRC). We recorded the behavior of each subject during a series of brief tests, involving exposure of each infant to a novel environment, to a social threat without the mother present, and to a novel environment with its mother present but sedated. We found significant heritability (h2) for willingness to move away from the mother and explore a novel environment (h2 = 0.25 ± 0.13; P = 0.003). The infants also exhibited a range of heritable behavioral reactions to separation stress or to threat when the mother was not present (h2 = 0.23 ± 0.13–0.24 ± 0.15, P < 0.01). We observed no evidence of maternal environmental effects on these traits. Our results extend knowledge of genetic influences on temperament and reactivity in nonhuman primates by demonstrating that several measures of behavioral reactivity among infant rhesus macaques are heritable.
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影响因子：
3.3
作者：
Embree, M.;Michopoulos, V.;Votaw, J. R.;Voll, R. J.;Mun, J.;Stehouwer, J. S.;Goodman, M. M.;Wilson, M. E.;Sanchez, M. M.
通讯作者：
Sanchez, M. M.
影响因子：
2.5
作者：
Kinnally, E. L.;Lyons, L. A.;Capitanio, J. P.
通讯作者：
Capitanio, J. P.
影响因子：
4.6
作者：
Brent LJ;Heilbronner SR;Horvath JE;Gonzalez-Martinez J;Ruiz-Lambides A;Robinson AG;Skene JH;Platt ML
通讯作者：
Platt ML
影响因子：
2.2
作者：
FAIRBANKS, LA;MCGUIRE, MT
通讯作者：
MCGUIRE, MT
DOI：
10.1097/01.alc.0000067976.62827.ed
发表时间：
2003-05-01
影响因子：
3.2
作者：
Barr, CS;Newman, TK;Higley, JD
通讯作者：
Higley, JD