The relation of developmental changes in brain serotonin transporter (5HTT) and 5HT1A receptor binding to emotional behavior in female rhesus monkeys: effects of social status and 5HTT genotype.
The relation of developmental changes in brain serotonin transporter (5HTT) and 5HT1A receptor binding to emotional behavior in female rhesus monkeys: effects of social status and 5HTT genotype.
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DOI：
10.1016/j.neuroscience.2012.10.016
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发表时间：
2013-01-03
期刊：
影响因子：
3.3
通讯作者：
Sanchez, M. M.
中科院分区：
文献类型：
--
作者：
Embree, M.;Michopoulos, V.;Votaw, J. R.;Voll, R. J.;Mun, J.;Stehouwer, J. S.;Goodman, M. M.;Wilson, M. E.;Sanchez, M. M.
本研究的目的是探讨社会从属压力和5-羟色胺（5-HT）基因多态性如何影响雌性恒河猴青春期过渡期脑5-HT系统的发育。我们还研究了与情绪反应的发展变化的关联，以应对标准化的行为测试，人类入侵者（HI）。我们的研究结果提供了第一个纵向证据的发展增加5 HT 1A受体和5 HTT结合在雌性灵长类动物的大脑从青春期前到围青春期。在这些社会圈养的雌性恒河猴中，5 HT 1A BPND的增加是一个强有力的发现，发生在所有组中，无论社会地位或5 HTT基因型如何，并且发生在所研究的所有前额叶区域的左半球和右半球，以及杏仁核，海马，下丘脑和中缝核。5 HTT BPND在中缝、前扣带皮层和背外侧前额叶皮层也显示出随年龄增加。大脑中5 HT系统的这些变化发生在女性建立更像成年人的社会行为模式时，以及HI范式期间。事实上，HI期间行为的主要发育变化（冻结增加和提交/姑息减少）与5 HT 1A受体和5 HTT的神经发育增加有关，因为这些行为和5 HT终点之间的关联出现在青春期前后。我们检测到社会地位对下丘脑中5 HT 1A BPND和眶额皮质中5 HTT BPND的影响，在青春期过渡期间，在这两种情况下，下属表现出比优势更高的BPND。5 HTT基因型对5 HT 1A和5 HTT BPND无主效应。我们的研究结果表明，雌性恒河猴的青春期是一个中央5 HT重组的时期，部分受社会压力的从属地位，这可能会整合肾上腺和性腺系统的功能和形状的行为反应，情感上具有挑战性的社会情况。
The goal of the present study was to examine how social subordination stress and 5HTT polymorphisms affect the development of brain serotonin (5HT) systems during the pubertal transition in female rhesus monkeys. We also examined associations with developmental changes in emotional reactivity in response to a standardized behavioral test, the Human Intruder (HI). Our findings provide the first longitudinal evidence of developmental increases in 5HT1A receptor and 5HTT binding in the brain of female primates from pre- to peripuberty. The increase in 5HT1A BPND in these socially housed female rhesus monkeys is a robust finding, occurring across all groups, regardless of social status or 5HTT genotype, and occurring in left and right hemispheres of all prefrontal regions studied, as well as amygdala, hippocampus, hypothalamus, and raphe nuclei. 5HTT BPND also showed an increase with age in raphe, anterior cingulate cortex, and dorsolateral prefrontal cortex. These changes in brain 5HT systems take place as females establish more adult-like patterns of social behavior, as well as during the HI paradigm. Indeed, the main developmental changes in behavior during the HI (increase in freezing and decrease in submission/appeasement) were related to neurodevelopmental increases in 5HT1A receptors and 5HTT, because the associations between these behaviors and 5HT endpoints emerge at peripuberty. We detected an effect of social status on 5HT1A BPND in the hypothalamus and on 5HTT BPND in the orbitofrontal cortex, with subordinates showing higher BPND than dominants in both cases during the pubertal transition. No main effects of 5HTT genotype were observed for 5HT1A or 5HTT BPND. Our findings indicate that adolescence in female rhesus monkeys is a period of central 5HT reorganization, partly influenced by exposure to the social stress of subordination, that likely functions to integrate adrenal and gonadal systems and shape the behavioral response to emotionally challenging social situations.
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