Affective context interferes with cognitive control in unipolar depression: an fMRI investigation.
Affective context interferes with cognitive control in unipolar depression: an fMRI investigation.
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DOI：
10.1016/j.jad.2008.06.027
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发表时间：
2009-04
影响因子：
6.6
通讯作者：
Smoski, Moria J.
中科院分区：
文献类型：
--
作者：
Dichter, Gabriel S.;Felder, Jennifer N.;Smoski, Moria J.
关键词：
单相重性抑郁障碍（MDD）的特征是杏仁核对悲伤刺激的异常反应和认知控制能力差，但这些障碍的相互作用尚不清楚。评估MDD患者对悲伤和中性情境中嵌入的认知控制刺激的大脑激活。14名患有抑郁症的成年人和15名匹配的对照参与了一项混合块/事件相关功能磁共振成像（fMRI）任务，该任务在悲伤或中性图像块中嵌入古怪的目标刺激。目标事件在两组中激活了相似的前额叶脑区。然而，对嵌入在情感图像块中的目标事件的反应显示出明显的群体分离。在中性阻滞，对照组表现出更大的激活，在额中回和前扣带回相对于MDD组的目标，复制以前的研究结果，前额叶低激活MDD样本的认知控制刺激。然而，在悲伤的块，抑郁症组表现出更大的激活，在一些前额叶区域，包括中，下，眶额回和前扣带回，这表明相对更多的前额叶脑激活需要脱离悲伤的图像，以响应目标事件。更大的样本量会提供更大的统计功效，更标准化的刺激会增加外部效度。这种双重分离的前额叶反应嵌入在中性和悲伤的背景下的目标事件表明，抑郁症的影响，不仅对情感事件的反应，但扩展到其他认知过程中进行的情感参与的背景下。这意味着在MDD中对悲伤事件的情绪反应可能比以前理解的更广泛地影响功能。
Unipolar major depressive disorder (MDD) is characterized by aberrant amygdala responses to sad stimuli and poor cognitive control, but the interactive effects of these impairments are poorly understood. To evaluate brain activation in MDD in response to cognitive control stimuli embedded within sad and neutral contexts. Fourteen adults with MDD and fifteen matched controls participated in a mixed block/event-related functional magnetic resonance imaging (fMRI) task that presented oddball target stimuli embedded within blocks of sad or neutral images. Target events activated similar prefrontal brain regions in both groups. However, responses to target events embedded within blocks of emotional images revealed a clear group dissociation. During neutral blocks, the control group demonstrated greater activation to targets in the midfrontal gyrus and anterior cingulate relative to the MDD group, replicating previous findings of prefrontal hypo-activation in MDD samples to cognitive control stimuli. However, during sad blocks, the MDD group demonstrated greater activation in a number of prefrontal regions, including the mid-, inferior, and orbito-frontal gyri and the anterior cingulate, suggesting that relatively more prefrontal brain activation was required to disengage from the sad images to respond to the target events. A larger sample size would have provided greater statistical power, and more standardized stimuli would have increased external validity. This double dissociation of prefrontal responses to target events embedded within neutral and sad context suggests that MDD impacts not only responses to affective events, but extends to other cognitive processes carried out in the context of affective engagement. This implies that emotional reactivity to sad events in MDD may impact functioning more broadly than previously understood.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
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作者：
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通讯作者：
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作者：
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DOI：
10.1053/scnp.2001.21837
发表时间：
2001-04-01
期刊：
Seminars in clinical neuropsychiatry
影响因子：
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作者：
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通讯作者：
Saxena, S
影响因子：
2.6
作者：
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通讯作者：
McCarthy, Gregory