Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review.
Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review.
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DOI：
10.1080/09540121.2016.1191612
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发表时间：
2016-12
期刊：
影响因子：
1.7
通讯作者：
Starrels JL
中科院分区：
文献类型：
--
作者：
Merlin JS;Bulls HW;Vucovich LA;Edelman EJ;Starrels JL
慢性疼痛发生在多达85%的艾滋病毒感染者中，并与实质性功能障碍有关。对于寻求解决患者慢性疼痛的艾滋病毒提供者来说，几乎没有指导。我们进行了一项系统性综述，以确定临床试验和观察性研究，这些研究检查了药物或非药物干预对高发展国家慢性疼痛HIV感染者疼痛和/或功能结局的影响。11项研究符合纳入标准，大多数是低质量或极低质量。七个检查药物干预（加巴喷丁，普瑞巴林，辣椒素，镇痛剂，包括阿片类药物）和四个检查非药物干预（认知行为疗法，自我催眠，吸食大麻）。唯一有阳性结果的对照研究是辣椒素和大麻，并且有短期随访（≤12周）。在7项药物干预研究中，有5项获得了制药业的大量赞助。这些发现突出了艾滋病毒/慢性疼痛文献中需要进一步研究的几个重要空白。
Chronic pain occurs in as many as 85% of individuals with HIV and is associated with substantial functional impairment. Little guidance is available for HIV providers seeking to address their patients’ chronic pain. We conducted a systematic review to identify clinical trials and observational studies that examined the impact of pharmacologic or non-pharmacologic interventions on pain and/or functional outcomes among HIV-infected individuals with chronic pain in high-development countries. Eleven studies met inclusion criteria and were mostly low or very low quality. Seven examined pharmacologic interventions (gabapentin, pregabalin, capsaicin, analgesics including opioids) and four examined non-pharmacologic interventions (cognitive behavioral therapy, self-hypnosis, smoked cannabis). The only controlled studies with positive results were of capsaicin and cannabis, and had short-term follow-up (≤12 weeks). Among the seven studies of pharmacologic interventions, five had substantial pharmaceutical industry sponsorship. These findings highlight several important gaps in the HIV/chronic pain literature that require further research.
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DOI：
10.1097/qai.0b013e3182662215
发表时间：
2012-10-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Merlin JS;Westfall AO;Raper JL;Zinski A;Norton WE;Willig JH;Gross R;Ritchie CS;Saag MS;Mugavero MJ
通讯作者：
Mugavero MJ
影响因子：
9.9
作者：
Simpson, David M.;Brown, Stephen;Tobias, Jeffrey
通讯作者：
Tobias, Jeffrey
影响因子：
9.9
作者：
Abrams, D. I.;Jay, C. A.;Petersen, K. L.
通讯作者：
Petersen, K. L.
影响因子：
2.6
作者：
Merlin, Jessica S.;Zinski, Anne;Hooten, W. Michael
通讯作者：
Hooten, W. Michael
影响因子：
3.3
作者：
Mazzotta, Elena;Agostinone, Adriana;Parruti, Giustino
通讯作者：
Parruti, Giustino