Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice.
Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice.
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DOI：
10.1186/1744-9081-7-29
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发表时间：
2011-08-01
期刊：
影响因子：
--
通讯作者：
Tarantino LM
中科院分区：
文献类型：
--
作者：
Eisener-Dorman AF;Grabowski-Boase L;Tarantino LM
The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors. C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine. Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice. Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
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影响因子：
2.9
作者：
BADIANI, A;BROWMAN, KE;ROBINSON, TE
通讯作者：
ROBINSON, TE
影响因子：
3.4
作者：
Cunningham, CL;Dickinson, SD;McMullin, CS
通讯作者：
McMullin, CS
影响因子：
3.5
作者：
Ito, Shinobu;Mori, Tomohisa;Sawaguchi, Toshiko
通讯作者：
Sawaguchi, Toshiko
DOI：
10.1097/01213011-199910000-00007
发表时间：
1999-10-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Jones, BC;Tarantino, LM;Erwin, VG
通讯作者：
Erwin, VG
影响因子：
3.6
作者：
Griffin, W. C., III;Randall, P. K.;Middaugh, L. D.
通讯作者：
Middaugh, L. D.