Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms.
Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms.
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DOI：
10.1007/s11605-009-1001-9
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发表时间：
2009-11
影响因子：
3.2
通讯作者：
Thayer, Sarah P.
中科院分区：
文献类型：
--
作者：
Bausch, Dirk;Mino-Kenudson, Mari;Fernandez-del Castillo, Carlos;Warshaw, Andrew L.;Kelly, Kimberly A.;Thayer, Sarah P.
胰腺导管内乳头状粘液性肿瘤（IPMN）现在越来越常见。在IPMN中检测癌症是困难的，并且具有高的假阳性和假阴性率，通常导致不适当的治疗决定。因此，使用新的生物标志物改善恶性肿瘤的检测可能会提高诊断准确性。一种这样有前途的新生物标志物是Plectin-1（Plec-1）。使用免疫组织化学，Plec-1的表达在良性（低度和中度异型增生，n=6）以及恶性IPMN（高度异型增生和浸润性癌，n=31）和淋巴结转移癌中产生的IPMN（n=12）进行了测定。此外，评价了良性（n=3）和恶性IPMN（n=4）的囊肿液的Plec-1表达。31例恶性IPMN中26例Plec-1阳性，12例淋巴结转移癌Plec-1阳性。相比之下，只有一个良性IPMN表达Plec-1。Plec-1鉴别良恶性IPMN的特异性为83%，敏感性为84%。此外，所有（四分之四）的囊肿液恶性IPMN，但没有三个良性IPMN，Plec-1阳性。这些数据支持Plec-1作为IPMN中产生的癌的早期检测的优良生物标志物。
Pancreatic intraductal papillary mucinous neoplasms (IPMN) are now identified with increasing frequency. The detection of carcinoma in IPMN is difficult and suffers from high false-positive and false-negative rates, often resulting in inappropriate treatment decisions. Improved detection of malignancy using novel biomarkers may therefore improve diagnostic accuracy. One such promising novel biomarker is Plectin-1 (Plec-1). Using immunohistochemistry, Plec-1 expression was assayed in benign (low and moderate dysplasia, n=6) as well as malignant IPMN (high-grade dysplasia and invasive carcinoma, n=31) and lymph node metastases from carcinoma arising in IPMN (n=12). Furthermore, cyst fluids from benign (n=3) and malignant IPMN (n=4) were evaluated for Plec-1 expression. Twenty-six of 31 malignant IPMN and all 12 lymph node metastases were Plec-1 positive. In contrast, only one of six benign IPMN expressed Plec-1. The specificity of Plec-1 in distinguishing malignant IPMN from benign IPMN was 83% and its sensitivity 84%. Furthermore, all (four out of four) cyst fluids from malignant IPMN, but none of the three benign IPMN, were Plec-1 positive. These data support Plec-1 as an excellent biomarker for the early detection of carcinoma arising in IPMN.
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影响因子：
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作者：
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