Rupture probability of porcine liver under planar and point loading
Rupture probability of porcine liver under planar and point loading
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平面和点载荷下猪肝脏的破裂概率
DOI：
10.1088/2057-1976/2/5/055018
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发表时间：
2016
影响因子：
1.4
通讯作者：
C. Wex
中科院分区：
文献类型：
--
作者：
S. Arndt;Russell;J. Tomas;P. Müller;S. Shekhar;K. Brandstädter;C. Bruns;C. Wex
在体内与操作和手术器械接触时，腹内器官受到不同程度的机械应力。由于腹部器官的分布式机械构成特性（例如刚度和强度）以及使用可能产生独特接触的不同类型的手术器械，器官上传递的负载通常可能基本上足以引起组织损伤或引发破裂。因此，对于不同负载条件下的破裂概率的表征是不可避免的，以防止外科手术期间器官损伤。在本文中，介绍了使用准静态单轴压缩和压痕测试对整个猪肝脏以及体外切割样品的材料行为（加载直至失效）的测量。测量的力-位移响应已使用一阶 Mooney-Rivlin 本构模型进行近似，从而确定了特征超弹性力学性能。使用对数正态分布和威布尔分布，比较了单轴压缩和压痕时加载力、接触位移、接触强度和体积韧性的破裂概率函数。结果表明，与压痕（几乎是点载荷）相比，通过单轴压缩（平面载荷）引发肝脏破裂需要更大的载荷和相应更高的变形功。除了实验结果之外，还提出了基于有限元方法的模拟，该模拟描述了由于摩擦效应引起的应力分布、样品变形和样品滑动。还提出了其他方面，例如破裂样本的组织学图像分析、破裂起源的预测以及破裂路径传播。
At in vivo contacts with operational and surgical instruments, intra-abdominal organs are mechanically stressed to varying degrees. Owing to the distributed mechanical constitutive properties (such as stiffness and strength) of abdominal organs and the usage of different types of surgical instruments which may create unique contacts, the transmitted load on the organ may often be substantially sufficient to cause tissue damage or initiate rupture. Thus, characterization of the rupture probability with respect to different loading conditions is an inevitable necessity to prevent damage of organs during surgical procedures. In this article, measurements of the material behavior (upon loading until failure) of whole porcine livers as well as cut samples in vitro using quasi-static uniaxial compression and indentation tests are presented. The measured force–displacement responses have been approximated using the first-order Mooney–Rivlin constitutive model and thereby, the characteristic hyperelastic mechanical properties have been determined. Using lognormal and Weibull distributions, a comparison of the rupture probability functions of the loading force, the contact displacement, the contact strength and the volumetric toughness at uniaxial compression and indentation are presented. It is shown that larger loads and correspondingly higher deformation work are necessary to initiate rupture in the liver by uniaxial compression (planar loading) in comparison to indentation (almost point loading). Besides the experimental results, finite element method based simulations which describe the stress distribution, sample deformation and sample slipping due to frictional effects are presented. Further aspects such as histological image analysis of ruptured samples, prediction of the rupture origin as well as rupture path propagation are presented.
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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