Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake.
Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake.
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DOI：
10.3389/fnins.2015.00056
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发表时间：
2015
影响因子：
4.3
通讯作者：
Knauf C
中科院分区：
文献类型：
--
作者：
Drougard A;Fournel A;Valet P;Knauf C
下丘脑是通过整合来自不同来源的大量信号(激素、神经递质、代谢物)来控制新陈代谢和食物摄取的关键区域。这些因素改变了下丘脑神经元的活动，并产生足够的分子和行为反应来控制能量平衡。在这个复杂的集成系统中，近年来提出了一个新的概念，即将活性氧物种(ROS)作为能量平衡的关键参与者。已知ROS不仅作用于不同外周器官的许多信号通路，而且作用于下丘脑，通过作用于不同类型的神经元，包括前阿片黑素皮质素(POMC)和刺鼠相关蛋白(AgRP)/神经肽Y(NPY)神经元来调节食物的摄取和代谢。下丘脑ROS的释放受到不同因素的影响，如胰腺和肠道激素，脂肪因子(瘦素，apelin，…)、神经递质和营养素(葡萄糖、血脂、…)。ROS的产生来源是多方面的，包括NADPH氧化酶，也包括被认为是大脑中主要ROS产生的线粒体。ROS被认为是信号分子，但反过来，这种神经元信号转导ROS途径的损伤会导致自主神经系统和神经内分泌功能的改变，导致肥胖和2型糖尿病等代谢性疾病。在这篇综述中，我们将注意力集中在能够调节下丘脑ROS释放以控制食物摄取和能量代谢的因素，以及这些因素的失控可能参与病理状态的发展。这一新的见解揭示了下丘脑中控制能量平衡的原始机制，并确定下丘脑ROS信号是治疗代谢紊乱的潜在治疗策略。
Hypothalamus is a key area involved in the control of metabolism and food intake via the integrations of numerous signals (hormones, neurotransmitters, metabolites) from various origins. These factors modify hypothalamic neurons activity and generate adequate molecular and behavioral responses to control energy balance. In this complex integrative system, a new concept has been developed in recent years, that includes reactive oxygen species (ROS) as a critical player in energy balance. ROS are known to act in many signaling pathways in different peripheral organs, but also in hypothalamus where they regulate food intake and metabolism by acting on different types of neurons, including proopiomelanocortin (POMC) and agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons. Hypothalamic ROS release is under the influence of different factors such as pancreatic and gut hormones, adipokines (leptin, apelin,…), neurotransmitters and nutrients (glucose, lipids,…). The sources of ROS production are multiple including NADPH oxidase, but also the mitochondria which is considered as the main ROS producer in the brain. ROS are considered as signaling molecules, but conversely impairment of this neuronal signaling ROS pathway contributes to alterations of autonomic nervous system and neuroendocrine function, leading to metabolic diseases such as obesity and type 2 diabetes. In this review we focus our attention on factors that are able to modulate hypothalamic ROS release in order to control food intake and energy metabolism, and whose deregulations could participate to the development of pathological conditions. This novel insight reveals an original mechanism in the hypothalamus that controls energy balance and identify hypothalamic ROS signaling as a potential therapeutic strategy to treat metabolic disorders.
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DOI：
10.1177/011542650201700105
发表时间：
2002-02-01
期刊：
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
影响因子：
--
作者：
Clark, Susan F
通讯作者：
Clark, Susan F
DOI：
10.1152/ajpheart.00619.2003
发表时间：
2004-08-01
影响因子：
4.8
作者：
Campese, VM;Ye, SH;Chiu, J
通讯作者：
Chiu, J
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
影响因子：
3.4
作者：
Andrews, Zane B.;Rivera, Alicia;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
影响因子：
11.4
作者：
AQUILA, H;LINK, TA;KLINGENBERG, M
通讯作者：
KLINGENBERG, M