Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990-2019 Findings from Global Burden of Disease Study 2019.
Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990-2019 Findings from Global Burden of Disease Study 2019.
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非风湿性钙化性主动脉瓣疾病的全球负担和改善差距：1990 年至 2019 年 2019 年全球疾病负担研究的结果
DOI：
10.3390/jcm11226733
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发表时间：
2022-11-14
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是探讨非风湿性钙化性主动脉瓣疾病（nrCAVD）的最新变化趋势，并揭示可能的改善措施。我们使用2019年全球疾病负担（GBD）研究的数据，分析了1990年至2019年nrCAVD的患病率、发病率、残疾调整生命年（DALYs）和死亡率趋势的年龄标准化率（asr）。采用Pearson相关系数分析asr与社会人口指数（SDI）的关系。通过分解和前沿分析，揭示了影响因素和可改进区域的贡献比例。2019年，全球共有940万（95%不确定区间（UI）： 807万至1089万）nrCAVD患者。1990 - 2019年nrCAVD患病率增加了155.47% (95% IU: 141.66% ~ 171.7%)，其中SDI中部地区增幅最大（821.11%,95% UI: 709.87% ~ 944.23%）。在全球范围内，nrCAVD的死亡率无显著变化（0.37%,95% UI:−8.85%至7.99%）。全球DALYs下降10.97% （95% UI:−17.94%至−3.46%）。高收缩压的人群归因分数（PAF）在15-49岁人群中升高，而在50岁以上人群中略有下降。人口增长是全球DALYs增长的主要因素（74.73%），而老龄化是高sdi地区DALYs增长的主要驱动因素（80.27%）。荷兰、芬兰、卢森堡、德国和挪威可以利用其社会人口资源降低nrCAVD的DALY率。根据这些结果，我们发现从1990年到2019年，在高sdi和高-中等sdi地区，nrCAVD负担显著增加。自2013年以来，nrCAVD的死亡率呈下降趋势，这可能与经导管主动脉瓣置换术的深入进展有关。一些国家可以利用其社会人口资源减轻非血管性疾病的负担。
The aim of this study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjusted life-years (DALYs), and mortality trends of nrCAVD from 1990 to 2019 using data from the Global Burden of Disease (GBD) study 2019. The relations between ASRs and socio-demographic index (SDI) were analyzed with Pearson’s correlation coefficients. Decomposition and frontier analysis were employed to reveal the contribution proportion of influence factors and regions where improvement can be achieved. In 2019, there were 9.40 million (95% uncertainty interval (UI): 8.07 to 10.89 million) individuals with nrCAVD globally. From 1990 to 2019, the prevalence rate of nrCAVD increased by 155.47% (95% IU: 141.66% to 171.7%), with the largest increase observed in the middle SDI region (821.11%, 95% UI: 709.87% to 944.23%). Globally, there were no significant changes in the mortality rate of nrCAVD (0.37%, 95% UI: −8.85% to 7.99%). The global DALYs decreased by 10.97% (95% UI: −17.94% to −3.46%). The population attributable fraction (PAF) of high systolic blood pressure increased in the population aged 15–49 years, while it declined slightly in population aged 50+ years. Population growth was the main contributing factor to the increased DALYs across the globe (74.73%), while aging was the driving force in the high-SDI region (80.27%). The Netherlands, Finland, Luxembourg, Germany, and Norway could reduce DALY rates of nrCAVD using their socio-demographic resources. According to these results, we revealed that the burden of nrCAVD increased markedly from 1990 to 2019 in high-SDI and high-middle-SDI regions. There was a downward trend in the mortality due to nrCAVD since 2013, which is possibly owing to profound advances in transcatheter aortic valve replacement. Some countries may reduce burdens of nrCAVD using their socio-demographic resources.
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DOI：
10.1016/s0140-6736(20)30925-9
发表时间：
2020-10-17
期刊：
Lancet (London, England)
影响因子：
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作者：
GBD 2019 Diseases and Injuries Collaborators
通讯作者：
GBD 2019 Diseases and Injuries Collaborators
DOI：
10.1016/s0735-1097(96)00563-3
发表时间：
1997-03-01
影响因子：
24
作者：
Stewart, BF;Siscovick, D;Otto, CM
通讯作者：
Otto, CM
影响因子：
2.8
作者：
Walsh, CR;Larson, MG;O'Donnell, CJ
通讯作者：
O'Donnell, CJ
DOI：
10.1016/j.ijcha.2022.100956
发表时间：
2022-04
期刊：
International journal of cardiology. Heart & vasculature
影响因子：
--
作者：
Arabloo J;Omidi N;Rezapour A;Sarabi Asiabar A;Mojtaba Ghorashi S;Azari S
通讯作者：
Azari S
DOI：
10.1016/s0140-6736(17)30818-8
发表时间：
2017-07-15
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2015 Healthcare Access and Quality Collaborators. Electronic address: cjlm@uw.edu;GBD 2015 Healthcare Access and Quality Collaborators
通讯作者：
GBD 2015 Healthcare Access and Quality Collaborators