Exhaled Nitric Oxide Increases During High Frequency Oscillatory Ventilation in Rabbits
Exhaled Nitric Oxide Increases During High Frequency Oscillatory Ventilation in Rabbits
复制标题
兔子高频振荡通气时呼出的一氧化氮增加
DOI：
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复制
发表时间：
1999
影响因子：
2.7
通讯作者：
L. Gustafsson
中科院分区：
文献类型：
--
作者：
A. Artlich;C. Adding;P. Agvald;M. Persson;P. Lönnqvist;L. Gustafsson
本研究比较了高频振荡通气（HFOV）和间歇指令通气（IMV）对健康家兔下呼吸道一氧化氮（NO）稳态的影响。进一步阐明了气道中NO形成的假定牵拉反应的机制。将雄性新西兰白色兔麻醉、气管切开并以随机顺序用IMV或HFOV通气。总NO排泄量从9.6 ± 0.8 nl min−1（平均值±s.e.m.）IMV时为22.6 ± 2.7 nl min−1（P <0.001）。功能残气量（ΔFRC）的变化不能解释这种增加。在恒定循环条件下，在离体缓冲液灌注肺中观察到HFOV期间NO排泄的类似增加（P < 0·05，n= 4）。在IMV和HFOV期间，在气管造口下方2.5cm、5cm、7.5cm和10cm处测量的肺内平均CO2和NO浓度随着进入肺的距离的增加而显著增加（每次比较P <0.001）。在采样导管的每个气管内位置，特别是气道中的低位置，HFOV期间的CO2和NO浓度均显著高于IMV期间（每次比较P <0.01）。我们的结论是，HFOV增加肺NO的生产在健康兔。HFOV期间呼吸系统的牵张激活增加被认为是可能的潜在机制。平均气道NO浓度的增加可能在呼吸道中具有生物学效应。它是否可以解释HFOV治疗的一些好处需要考虑。
This study compared the effects of high frequency oscillatory ventilation (HFOV) and intermittent mandatory ventilation (IMV) on the homeostasis of nitric oxide (NO) in the lower respiratory tract of healthy rabbits. The mechanisms underlying a putative stretch response of NO formation in the airways were further elucidated. Male New Zealand White rabbits were anaesthetized, tracheotomized and ventilated with IMV or HFOV in random order. Total NO excretion increased from 9·6 ± 0·8 nl min−1 (mean ±s.e.m.) during IMV to 22·6 ± 2·7 nl min−1 during HFOV (P < 0·001). This increase was not explained by changes of functional residual capacity (ΔFRC). A similar increase in NO excretion during HFOV was seen in isolated buffer‐perfused lungs under constant circulatory conditions (P < 0·05, n= 4). Intratracheal mean CO2 and NO concentrations, measured at 2·5, 5, 7·5 and 10 cm below tracheostomy, increased significantly with increasing distance into the lung during both IMV and HFOV (P < 0·001 for each comparison). At every intratracheal location of the sampling catheter, particularly low in the airways, both CO2 and NO concentrations were significantly higher during HFOV than during IMV (P < 0·01 for each comparison). We conclude that HFOV increases pulmonary NO production in healthy rabbits. Increased stretch activation of the respiratory system during HFOV is suggested as a possible underlying mechanism. The increase in mean airway NO concentrations may have biological effects in the respiratory tract. Whether it can account for some of the benefits of HFOV treatment needs to be considered.
用于肺气道气体采样的同心导管的构造和使用。
DOI：
10.1152/jappl.1993.74.6.3063
发表时间：
1993
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Gavriely,N;Solway,J;Elad,D;Shabtai-Musih,Y;Gaver3rd,DP;Grotberg,JB;Drazen,JM
通讯作者：
Drazen,JM
影响因子：
15.9
作者：
AWOLESI, MA;SESSA, WC;SUMPIO, BE
通讯作者：
SUMPIO, BE
犬气管充气时高频胸部振动期间气道内气体输送。
DOI：
10.1152/jappl.1995.79.1.243
发表时间：
1995
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Gavriely,N;Eckmann,DM;Grotberg,JB
通讯作者：
Grotberg,JB