Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation.
Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation.
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DOI：
10.1016/j.cytogfr.2009.07.007
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发表时间：
2009-08
影响因子：
13
通讯作者：
Cheng, C. Yan
中科院分区：
文献类型：
--
作者：
Li, Michelle W. M.;Mruk, Dolores D.;Lee, Will M.;Cheng, C. Yan
关键词：
在哺乳动物睾丸的精子发生过程中，支持细胞-支持细胞和支持细胞-生殖细胞界面发生连接重组，这与细胞周期进展和生精上皮中生殖细胞的易位等发育相结合。在大鼠睾丸中，在生精上皮周期的第八阶段，基底区域附近的支持细胞之间形成的血睾屏障（BTB）的重建以及支持细胞与生精上皮管腔边缘完全发育的精子细胞（精子）之间的顶端外质特化（顶端ES）的破坏同时发生。这两个过程分别对于初级精母细胞从基部移位到顶端室以准备减数分裂以及在精子形成时将精子释放到曲细精上皮的内腔至关重要。在上皮周期的这个阶段，细胞因子，例如 TNFα 和 TGFβ3，在上皮微环境中以高水平存在。由于这些细胞因子被证明会破坏 BTB 完整性和生殖细胞粘附，因此有人提出，从生殖细胞（特别是初级精母细胞和支持细胞）释放的一些细胞因子将在生精上皮周期的第 VIII 阶段诱导 BTB 和顶端 ES 的连接重建。在这篇综述中，我们将讨论细胞因子和睾酮在调节 BTB 处初级精母细胞转运和精子形成中的复杂作用。还将讨论介导细胞因子诱导的连接重组的可能调节因子，包括间隙连接和细胞外基质。
During spermatogenesis in mammalian testes, junction restructuring takes place at the Sertoli-Sertoli and Sertoli-germ cell interface, which is coupled with the development, such as cell cycle progression, and translocation of the germ cell in the seminiferous epithelium. In the rat testis, the restructuring of the blood-testis barrier (BTB) formed between Sertoli cells near the basal region and the disruption of the apical ectoplasmic specialization (apical ES) between Sertoli cells and fully developed spermatids (spermatozoa) at the luminal edge of the seminiferous epithelium occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis. These two processes are essential for the translocation of primary spermatocytes from the basal to the apical compartment to prepare for meiosis, and the release of spermatozoa to the lumen of the seminiferous epithelium at spermiation, respectively. Cytokines, such as TNFα and TGFβ3, are present at high level in the microenvironment of the epithelium at this stage of the epithelial cycle. Since these cytokines were shown to disrupt the BTB integrity and germ cell adhesion, it was proposed that some cytokines released from germ cells particularly primary spermatocytes and Sertoli cells, would induce the junction restructuring of the BTB and apical ES at stage VIII of the seminiferous epithelial cycle. In this review, the intricate role of cytokines and testosterone to regulate the transit of primary spermatocytes at the BTB and spermiation will be discussed. Possible regulators that mediate the cytokine-induced junction restructuring, including the gap junction and extracellular matrix, will also be discussed.
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影响因子：
3.6
作者：
Han, Cecil;Choi, Eunyoung;Cho, Chunghee
通讯作者：
Cho, Chunghee
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影响因子：
7.8
作者：
Carragher, N O;Levkau, B;Ross, R;Raines, E W
通讯作者：
Raines, E W
影响因子：
4
作者：
Fiorini, C;Mograbi, B;Pointis, G
通讯作者：
Pointis, G
影响因子：
--
作者：
HERMO, L;DWORKIN, J
通讯作者：
DWORKIN, J
影响因子：
4.1
作者：
Delfino, FJ;Boustead, JN;Walker, WH
通讯作者：
Walker, WH