Two polymorphisms in the TIM‐4 gene are associated with asthma in a Chinese Han population
Two polymorphisms in the TIM‐4 gene are associated with asthma in a Chinese Han population
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TIM-4基因的两个多态性与中国汉族人群的哮喘相关
DOI：
10.1111/j.1744-313x.2010.00965.x
复制
发表时间：
2011
影响因子：
2.2
通讯作者：
Q. Liu
中科院分区：
文献类型：
--
作者：
B. Zhao;G. Abdelmoudjib;J. Li;H. Li;C. Wei;Y. Gong;Q. Liu
T细胞免疫球蛋白和粘蛋白结构域(TIM)基因家族编码细胞表面受体，参与Th1和Th2细胞免疫的调节。已发现TIM-1基因与几个人群的哮喘有关。TIM-1天然配体TIM-4可能影响哮喘的易感性，探讨TIM-4基因多态性与中国汉族人群哮喘的关系。对551例哮喘患者和549例健康对照TIM-4基因rs6882076、rs12658558和rs4702747三个单核苷酸多态性进行基因分型。我们发现TIM-4基因的两个单核苷酸多态rs6882076和rs4702747与本研究人群的哮喘易感性相关(P值分别为 0.009和0.005)。未观察到哮喘与rs12658558之间的关联。我们的结果提示TIM-4基因多态性与中国汉族人群哮喘相关。
The gene family of the T cell immunoglobulin and mucin domain (TIM) proteins encodes cell surface receptors that are involved in the regulation of Th1‐ and Th2‐cell‐mediated immunity. TIM‐1 gene has been found to be associated with asthma in several populations. TIM‐4, the natural ligand for TIM‐1, may influence the susceptility to asthma.To investigate the association of the TIM‐4 gene polymorphisms with asthma in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in TIM‐4 gene, rs6882076, rs12658558 and rs4702747, were genotyped in 551 unrelated asthma patients and 549 healthy controls. We found that two SNPs of the TIM‐4 gene, rs6882076 and rs4702747, were associated with asthma susceptibility in our study population (with P‐values = 0.009 and 0.005 respectively). No association was observed between asthma and rs12658558. Our results suggest that TIM‐4 gene polymorphisms are associated with asthma in a Chinese Han population.
影响因子：
4.4
作者：
Walley, AJ;Wiltshire, S;Cookson, WOCM
通讯作者：
Cookson, WOCM