Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae.
Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae.
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DOI：
10.3389/fcimb.2021.643326
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发表时间：
2021
影响因子：
5.7
通讯作者：
Henriques-Normark B
中科院分区：
文献类型：
--
作者：
Sender V;Hentrich K;Henriques-Normark B
继发性细菌感染大大增加了流感感染的疾病负担。肺炎链球菌（肺炎球菌）在细菌和病毒病原体之间的协同作用中发挥着重要作用，这种协同作用基于病原体和宿主免疫反应之间复杂的相互作用。在这里，我们讨论流感感染后继发性肺炎球菌感染的发病机制，重点是肺炎球菌如何感知和适应流感修饰的环境。我们简要总结了与 COVID-19 相关的继发细菌感染的已知情况，并强调需要改进我们当前预防和治疗病毒细菌合并感染的策略。
Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which is based on complex interactions between the pathogen and the host immune response. Here, we discuss mechanisms that drive the pathogenesis of a secondary pneumococcal infection after an influenza infection with a focus on how pneumococci senses and adapts to the influenza-modified environment. We briefly summarize what is known regarding secondary bacterial infection in relation to COVID-19 and highlight the need to improve our current strategies to prevent and treat viral bacterial coinfections.
影响因子：
4.5
作者：
Mücke PA;Ostrzinski A;Hammerschmidt S;Maaß S;Becher D
通讯作者：
Becher D
DOI：
10.4049/jimmunol.1201916
发表时间：
2012-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Haynes L;Szaba FM;Eaton SM;Kummer LW;Lanthier PA;Petell AH;Duso DK;Luo D;Lin JS;Lefebvre JS;Randall TD;Johnson LL;Kohlmeier JE;Woodland DL;Smiley ST
通讯作者：
Smiley ST
影响因子：
12.7
作者：
van Someren Gréve F;van der Sluijs KF;Tuip AM;Schultz MJ;de Jong MD;Juffermans NP
通讯作者：
Juffermans NP