Interactions between the gut microbiota-derived functional factors and intestinal epithelial cells - implication in the microbiota-host mutualism.
Interactions between the gut microbiota-derived functional factors and intestinal epithelial cells - implication in the microbiota-host mutualism.
复制标题
肠道微生物源性功能因子与肠上皮细胞之间的相互作用-微生物-宿主互惠共生的意义。
DOI：
10.3389/fimmu.2022.1006081
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发表时间：
2022
影响因子：
7.3
通讯作者：
Yan, Fang
中科院分区：
文献类型：
--
作者：
Kaur, Harpreet;Ali, Syed Azmal;Yan, Fang
关键词：
肠道微生物群与宿主之间的相互作用在维持人体健康和为肠道微生物群落提供营养丰富的环境方面发挥着重要作用。肠上皮细胞（IEC）提供对肠道微生物群的前线反应，以维持肠道内稳态。新出现的证据指出，肠道细菌衍生的组分是肠道细菌作用的功能因子，包括保护肠道完整性和减轻肠道炎症的易感性。此外，已经发现IEC与肠道细菌沟通，以塑造微生物群落的组成和功能。本综述将讨论目前的理解的有益影响的功能因子分泌的肠道细菌对IEC，重点是可溶性蛋白质，代谢产物和表面层成分，并强调IEC的肠道微生物的影响。这些知识为理解微生物-宿主互惠共生的机制提供了概念验证模型。
Mutual interactions between the gut microbiota and the host play essential roles in maintaining human health and providing a nutrient-rich environment for the gut microbial community. Intestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Emerging evidence points to commensal bacterium-derived components as functional factors for the action of commensal bacteria, including protecting intestinal integrity and mitigating susceptibility of intestinal inflammation. Furthermore, IECs have been found to communicate with the gut commensal bacteria to shape the composition and function of the microbial community. This review will discuss the current understanding of the beneficial effects of functional factors secreted by commensal bacteria on IECs, with focus on soluble proteins, metabolites, and surface layer components, and highlight the impact of IECs on the commensal microbial profile. This knowledge provides a proof-of-concept model for understanding of mechanisms underlying the microbiota-host mutualism.
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DOI：
10.1038/nrmicro3552
发表时间：
2016-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Donaldson GP;Lee SM;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
3.7
作者：
Claes IJ;Schoofs G;Regulski K;Courtin P;Chapot-Chartier MP;Rolain T;Hols P;von Ossowski I;Reunanen J;de Vos WM;Palva A;Vanderleyden J;De Keersmaecker SC;Lebeer S
通讯作者：
Lebeer S
影响因子：
4.4
作者：
Corcoran, BM;Stanton, C;Ross, RP
通讯作者：
Ross, RP
影响因子：
1.2
作者：
Baeuerl, Christine;Perez-Martinez, Gaspar;Monedero, Vicente
通讯作者：
Monedero, Vicente
影响因子：
32.4
作者：
Ganal, Stephanie C.;Sanos, Stephanie L.;Diefenbach, Andreas
通讯作者：
Diefenbach, Andreas