Association of handgrip strength with hospitalization, cardiovascular events, and mortality in Japanese patients with type 2 diabetes.
Association of handgrip strength with hospitalization, cardiovascular events, and mortality in Japanese patients with type 2 diabetes.
复制标题
日本 2 型糖尿病患者的握力与住院、心血管事件和死亡率之间的关系。
DOI：
10.1038/s41598-017-07438-8
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发表时间：
2017-08-01
影响因子：
4.6
通讯作者：
Yanai H
中科院分区：
文献类型：
--
作者：
Hamasaki H;Kawashima Y;Katsuyama H;Sako A;Goto A;Yanai H
握力对肌肉减少症的诊断是有用的。我们研究了握力与2型糖尿病患者全因死亡率、心血管事件和住院的关系。2013年4月至2015年12月，我们对在我院测量握力的2型糖尿病患者进行回顾性队列研究。所有患者随访至2016年5月。共纳入1282例患者（63.8±13.9年），随访时间为2.36±0.73年。随访期间死亡20例（1.6%），发生心血管事件14例（1.1%），因各种疾病住院556例（43.4%）。多元回归分析显示，握力与腹部肥胖和肾功能呈正相关。此外，校正潜在混杂变量的Cox比例风险分析显示，所有受试者的握力与CVD事件的发生和住院率显著相关。此外，握力与男性的死亡率和住院率以及女性的住院率显著相关。握力可能是日本2型糖尿病患者健康状况的预后指标，也是骨骼肌质量损失的诊断标志。
Handgrip strength is useful for the diagnosis of sarcopenia. We examined the associations of handgrip strength with all-cause mortality, cardiovascular events, and hospitalization in patients with type 2 diabetes. From April 2013 to December 2015, we conducted a retrospective cohort study to examine patients with type 2 diabetes whose handgrip strength was measured at our hospital. All patients were followed up until May 2016. A total of 1,282 patients (63.8 ± 13.9 years) were enrolled and followed up for 2.36 ± 0.73 years. During the follow-up period, 20 patients (1.6%) died, 14 (1.1%) experienced cardiovascular events, and 556 (43.4%) were admitted to our hospital for any diseases. Multiple regression analyses revealed that handgrip strength was favorably associated with abdominal obesity and renal function. Moreover, Cox proportional hazard analyses with adjustment for potential confounding variables revealed that handgrip strength was significantly associated with occurrence of CVD events and hospitalization in all subjects. In addition, handgrip strength was significantly associated with mortality and hospitalization in men and with hospitalization in women. Handgrip strength could be a prognostic indicator for health as well as a diagnostic marker of skeletal muscle mass loss in Japanese patients with type 2 diabetes.
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影响因子：
4.7
作者：
Batsis, J. A.;Mackenzie, T. A.;Bartels, S. J.
通讯作者：
Bartels, S. J.
影响因子：
5.1
作者：
Cetinus, E;Buyukbese, MA;Karaoguz, A
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Karaoguz, A
影响因子：
5.3
作者：
Eguchi, Kazuo;Hoshide, Satoshi;Kario, Kazuomi
通讯作者：
Kario, Kazuomi
影响因子：
7.7
作者：
Joyner MJ;Limberg JK
通讯作者：
Limberg JK
影响因子：
7.2
作者：
Fagour, C.;Gonzalez, C.;Rigalleau, V.
通讯作者：
Rigalleau, V.