Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet.
Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet.
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DOI：
10.1093/cvr/cvaa069
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发表时间：
2021-02-22
影响因子：
10.8
通讯作者：
Brandt KJ
中科院分区：
文献类型：
--
作者：
Burger F;Miteva K;Baptista D;Roth A;Fraga-Silva RA;Martel C;Stergiopulos N;Mach F;Brandt KJ
B细胞在动脉粥样硬化形成过程中的功能已被研究，但仍有几个方面有待澄清。在这项研究中，我们表明，卵泡调节辅助T细胞（TFR）控制调节B细胞（布雷格）人口在Apoe−/−小鼠模型的高胆固醇饮食（HCD）。用HCD喂养小鼠导致TFR和布雷格细胞群的上调，导致致动脉粥样硬化性滤泡辅助T细胞（TFH）反应的抑制。TFH细胞调节与胸腹联合动脉粥样硬化斑块和主动脉根部斑块中动脉粥样硬化斑块大小的增长相关，表明TFR细胞具有动脉粥样硬化保护作用。在过继转移实验中，转移到HCD小鼠中的TFR细胞减少了TFH细胞群，动脉粥样硬化斑块大小，而布雷格细胞群和淋巴管生成显著增加。我们的研究结果表明，通过不同的策略，TFR和TFH细胞调节Apoe−/−小鼠模型中的抗动脉粥样硬化和促动脉粥样硬化免疫过程，因为TFR细胞能够调节TFH和布雷格细胞群以及淋巴管生成和脂蛋白代谢。
B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe−/− mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BREG cell populations, causing the suppression of proatherogenic follicular helper T cell (TFH) response. TFH cell modulation is correlated with the growth of atherosclerotic plaque size in thoracoabdominal aortas and aortic root plaques, suggesting that TFR cells are atheroprotective. During adoptive transfer experiments, TFR cells transferred into HCD mice decreased TFH cell populations, atherosclerotic plaque size, while BREG cell population and lymphangiogenesis are significantly increased. Our results demonstrate that, through different strategies, both TFR and TFH cells modulate anti- and pro-atherosclerotic immune processes in an Apoe−/− mice model since TFR cells are able to regulate both TFH and BREG cell populations as well as lymphangiogenesis and lipoprotein metabolism.
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影响因子：
37.8
作者：
Maganto-García E;Tarrio ML;Grabie N;Bu DX;Lichtman AH
通讯作者：
Lichtman AH
影响因子：
82.9
作者：
Gomez D;Baylis RA;Durgin BG;Newman AAC;Alencar GF;Mahan S;St Hilaire C;Müller W;Waisman A;Francis SE;Pinteaux E;Randolph GJ;Gram H;Owens GK
通讯作者：
Owens GK
影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
15.9
作者：
Cheng, Hsin-Yuan;Gaddis, Dalia E.;Hedrick, Catherine C.
通讯作者：
Hedrick, Catherine C.
影响因子：
4.4
作者：
Kyaw, Tin;Tay, Christopher;Toh, Ban-Hock
通讯作者：
Toh, Ban-Hock